Study on strontium doped tricalcium silicate synthesized through sol-gel process

Wai Ching Liu, Chih Chien Hu, Yuan Yun Tseng, Rajalakshmi Sakthivel, Kuei Sheng Fan, An Ni Wang, Yi Min Wang, Ren Jei Chung

Research output: Contribution to journalArticlepeer-review

19 Citations (Scopus)


We successfully synthesized a strontium-doped tricalcium silicate (SrxCa3 xSiO5, Sr = 0 to 2 mol%) bone cement using the sol-gel process. The material properties including crystallinity, setting time, mechanical strength, and hydration products were characterized. Release of ions and pH values of simulated body fluid soaked with the bone cement were measured. In vitro biocompatibility of different concentrations of the material was evaluated by the viability of L929 cells. The setting times of as-prepared slurries were all <70 min. Doping with 0.5 mol% Sr reduced the final setting time by 20 min. After 14 days curing, 0.25 mol% Sr-doped SrxCa3 xSiO5 possessed the highest compressive strength of 45 MPa among all the Sr-doped groups with no statistical difference to Ca3SiO5. The bioactivity of the materials was confirmed with the formation of an apatite layer on the surface of the materials after immersion in simulated body fluid. In addition, the proliferation of L929 cells exposed to 1 mol% Sr was significantly promoted as compared to no Sr doping. SrxCa3 xSiO5 is a novel and advanced material that has the potential to serve as a bone cement in bone restoration with appropriate mechanical strength and favorable biocompatibility.

Original languageEnglish
Article number110431
JournalMaterials Science and Engineering C
Publication statusPublished - Mar 2020


  • Biocompatibility
  • Bone cement
  • Sol-gel process
  • Strontium
  • Tricalcium silicate

ASJC Scopus subject areas

  • Materials Science(all)
  • Condensed Matter Physics
  • Mechanics of Materials
  • Mechanical Engineering


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