Study of the natural product intermediates of steviolbioside, steviol, and isosteviol; O- and N-acylated forms of benzotriazoyl esters

Lin Wen Lee, Shih Ming Chen, Chiung Chang Lin, Shiow Yunn Sheu, Pen Yuan Lin

Research output: Contribution to journalArticle


Glycosides, steviolside, and rubaudioside A, which are extracted from the leaves of Stevia rebaudiana, can be used as sweetener for food additive. Intermediates of steviolbioside, steviol, and isosteviol are very stable compounds obtained from benzotriazol-1-yloxtri(pyrrolidinol)phosphonium hexafluorophosphate. They are suitable to be used in amide and amide dimer synthesis. These nature product intermediates possess special characteristics. The spectra data showed two tautomeric groups: an ester form and an amide form. Their nuclear magnetic resonance, mass and chromatographic/mass/mass spectra were examined.

Original languageEnglish
Pages (from-to)1232-1236
Number of pages5
JournalJournal of the Chinese Chemical Society
Issue number6
Publication statusPublished - 2010



  • Benzotriazole-1-yl-oxy- trispyrrolidinophosphoniumhexafluorophosphate
  • Isosteviol-benzotrazol ester
  • Steviol
  • Steviolbioside

ASJC Scopus subject areas

  • Chemistry(all)

Cite this