Structure-based inhibitors exhibit differential activities against Helicobacter pylori and Escherichia coli undecaprenyl pyrophosphate synthases

Chih Jung Kuo, Rey Ting Guo, I. Lin Lu, Hun Ge Liu, Su Ying Wu, Tzu Ping Ko, Andrew H.J. Wang, Po Huang Liang

Research output: Contribution to journalArticlepeer-review

32 Citations (Scopus)

Abstract

Helicobacter pylori colonizes the human gastric epithelium and causes diseases such as gastritis, peptic ulcers, and stomach cancer. Undecaprenyl pyrophosphate synthase (UPPS), which catalyzes consecutive condensation reactions of farnesyl pyrophosphate with eight isopentenyl pyrophosphate to form lipid carrier for bacterial peptidoglycan biosynthesis, represents a potential target for developing new antibiotics. In this study, we solved the crystal structure of H. pylori UPPS and performed virtual screening of inhibitors from a library of 58,635 compounds. Two hits were found to exhibit differential activities against Helicobacter pylori and Escherichia coli UPPS, giving the possibility of developing antibiotics specially targeting pathogenic H. pylori without killing the intestinal E. coli.

Original languageEnglish
Article number841312
JournalJournal of Biomedicine and Biotechnology
Volume2008
Issue number1
DOIs
Publication statusPublished - 2008
Externally publishedYes

ASJC Scopus subject areas

  • Biotechnology
  • Molecular Medicine
  • Molecular Biology
  • Genetics
  • Health, Toxicology and Mutagenesis

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