Structure and bioactivity of the polysaccharides in medicinal plant Dendrobium huoshanense

Yves S.Y. Hsieh, Cheng Chien, Sylvian K.S. Liao, Shih Fen Liao, Wei Ting Hung, Wen Bin Yang, Chih Chien Lin, Ting Jen Rachel Cheng, Chia Chuan Chang, Jim Min Fang, Chi Huey Wong

Research output: Contribution to journalArticle

110 Citations (Scopus)

Abstract

Detailed structures of the active polysaccharides extracted from the leaf and stem cell walls and mucilage of Dendrobium huoshanense are determined by using various techniques, including chromatographic, spectroscopic, chemical, and enzymatic methods. The mucilage polysaccharide exhibits specific functions in activating murine splenocytes to produce several cytokines including IFN-γ, IL-10, IL-6, and IL-1α, as well as hematopoietic growth factors GM-CSF and G-CSF. However, the deacetylated mucilage obtained from an alkaline treatment fails to induce cytokine production. The structure and bioactivity of mucilage components are validated by further fractionation. This is the first study that provides clear evidence for the structure and activity relationship of the polysaccharide in D. huoshanense.

Original languageEnglish
Pages (from-to)6054-6068
Number of pages15
JournalBioorganic and Medicinal Chemistry
Volume16
Issue number11
DOIs
Publication statusPublished - Jun 1 2008
Externally publishedYes

Keywords

  • Cell wall
  • Dendrobium huoshanense
  • Immune response
  • Mucilage
  • Polysaccharide
  • Structure

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Medicine
  • Molecular Biology
  • Pharmaceutical Science
  • Drug Discovery
  • Clinical Biochemistry
  • Organic Chemistry

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  • Cite this

    Hsieh, Y. S. Y., Chien, C., Liao, S. K. S., Liao, S. F., Hung, W. T., Yang, W. B., Lin, C. C., Cheng, T. J. R., Chang, C. C., Fang, J. M., & Wong, C. H. (2008). Structure and bioactivity of the polysaccharides in medicinal plant Dendrobium huoshanense. Bioorganic and Medicinal Chemistry, 16(11), 6054-6068. https://doi.org/10.1016/j.bmc.2008.04.042