Structure activity of topoisomerase i poisons related to hoechst 33342

Qun Sun, Barbra Gatto, Chiang Yu, Angela Liu, Leroy-Fong Liu, Edmond J. LaVoie

Research output: Contribution to journalArticle

54 Citations (Scopus)

Abstract

A series of bisbenzimidazoles related to Hoechst 33342 were synthesized. Data on the relative activity of these bisbenzimidazoles as topoisomerase I poisons suggest that considerable flexibility exists in the location of the tertiary alkylamine moeity. With the exception of arylamine analogs, cytotoxicity was generally consistent with their relative potency as topoisomerase I poisons.

Original languageEnglish
Pages (from-to)2871-2876
Number of pages6
JournalBioorganic and Medicinal Chemistry Letters
Volume4
Issue number24
DOIs
Publication statusPublished - Dec 22 1994
Externally publishedYes

Fingerprint

Type I DNA Topoisomerase
Poisons
Cytotoxicity
HOE 33342

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Organic Chemistry
  • Drug Discovery
  • Pharmaceutical Science

Cite this

Structure activity of topoisomerase i poisons related to hoechst 33342. / Sun, Qun; Gatto, Barbra; Yu, Chiang; Liu, Angela; Liu, Leroy-Fong; LaVoie, Edmond J.

In: Bioorganic and Medicinal Chemistry Letters, Vol. 4, No. 24, 22.12.1994, p. 2871-2876.

Research output: Contribution to journalArticle

Sun, Qun ; Gatto, Barbra ; Yu, Chiang ; Liu, Angela ; Liu, Leroy-Fong ; LaVoie, Edmond J. / Structure activity of topoisomerase i poisons related to hoechst 33342. In: Bioorganic and Medicinal Chemistry Letters. 1994 ; Vol. 4, No. 24. pp. 2871-2876.
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