Structure-activity and crystallographic analysis of benzophenone derivatives - The potential anticancer agents

Hsing Pang Hsieh, Jing Ping Liou, Ying Ting Lin, Neeraj Mahindroo, Jang Yang Chang, Yung Ning Yang, Shuenn Shing Chern, Uan Kang Tan, Chun Wei Chang, Tung Wei Chen, Chi Hung Lin, Ying Ying Chang, Chiung Chiu Wang

Research output: Contribution to journalArticle

72 Citations (Scopus)

Abstract

Compounds 1-5, structurally related to combretastatin A-4 showed excellent cytotoxic activities against a panel of human cancer cell lines including multi-drug resistant cell lines. The X-ray three-dimensional structural analysis shows that proton donor in B ring may be required for cytotoxic activity, with intermolecular hydrogen bonding playing an important role.

Original languageEnglish
Pages (from-to)101-105
Number of pages5
JournalBioorganic and Medicinal Chemistry Letters
Volume13
Issue number1
DOIs
Publication statusPublished - Jan 6 2003
Externally publishedYes

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Antineoplastic Agents
Cells
Derivatives
Cell Line
Hydrogen Bonding
Structural analysis
Protons
Hydrogen bonds
X-Rays
X rays
Pharmaceutical Preparations
Neoplasms
benzophenone
fosbretabulin

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Organic Chemistry
  • Drug Discovery
  • Pharmaceutical Science

Cite this

Structure-activity and crystallographic analysis of benzophenone derivatives - The potential anticancer agents. / Hsieh, Hsing Pang; Liou, Jing Ping; Lin, Ying Ting; Mahindroo, Neeraj; Chang, Jang Yang; Yang, Yung Ning; Chern, Shuenn Shing; Tan, Uan Kang; Chang, Chun Wei; Chen, Tung Wei; Lin, Chi Hung; Chang, Ying Ying; Wang, Chiung Chiu.

In: Bioorganic and Medicinal Chemistry Letters, Vol. 13, No. 1, 06.01.2003, p. 101-105.

Research output: Contribution to journalArticle

Hsieh, HP, Liou, JP, Lin, YT, Mahindroo, N, Chang, JY, Yang, YN, Chern, SS, Tan, UK, Chang, CW, Chen, TW, Lin, CH, Chang, YY & Wang, CC 2003, 'Structure-activity and crystallographic analysis of benzophenone derivatives - The potential anticancer agents', Bioorganic and Medicinal Chemistry Letters, vol. 13, no. 1, pp. 101-105. https://doi.org/10.1016/S0960-894X(02)00850-8
Hsieh, Hsing Pang ; Liou, Jing Ping ; Lin, Ying Ting ; Mahindroo, Neeraj ; Chang, Jang Yang ; Yang, Yung Ning ; Chern, Shuenn Shing ; Tan, Uan Kang ; Chang, Chun Wei ; Chen, Tung Wei ; Lin, Chi Hung ; Chang, Ying Ying ; Wang, Chiung Chiu. / Structure-activity and crystallographic analysis of benzophenone derivatives - The potential anticancer agents. In: Bioorganic and Medicinal Chemistry Letters. 2003 ; Vol. 13, No. 1. pp. 101-105.
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