Structural insights into RbmA, a biofilm scaffolding protein of V. cholerae

Manuel Maestre-Reyna, Wen Jin Wu, Andrew H.J. Wang

Research output: Contribution to journalArticlepeer-review

25 Citations (Scopus)

Abstract

V. cholerae can form sessile biofilms associated with abiotic surfaces, cyanobacteria, zoo-plankton, mollusks, or crustaceans. Along with the vibrio polysaccharide, secreted proteins of the rbm gene cluster are key to the biofilm ultrastructure. Here we provide a thorough structural characterization of RbmA, a protein involved in mediating cellcell and cell-biofilm contacts. We correlate our structural findings with initial ligand specificity screening results, NMR protein-ligand interaction analysis, and complement our results with a full biocomputational study.

Original languageEnglish
Article numbere82458
JournalPLoS ONE
Volume8
Issue number12
DOIs
Publication statusPublished - Dec 5 2013
Externally publishedYes

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Agricultural and Biological Sciences(all)
  • General

Fingerprint

Dive into the research topics of 'Structural insights into RbmA, a biofilm scaffolding protein of V. cholerae'. Together they form a unique fingerprint.

Cite this