Stromal cell-derived factor-1 but not its receptor, CXCR4, gene variants increase susceptibility and pathological development of hepatocellular carcinoma

Chi Chung Chang, Shu Chen Chen, Yi Hsien Hsieh, Yi Chen Chen, Tzy Yen Chen, Yin Hung Chu, Hui Jen Ma, Ming Chih Chou, Hsiu Ting Tsai, Shun Fa Yang

Research output: Contribution to journalArticle

36 Citations (Scopus)

Abstract

Background: Hepatocellular carcinoma (HCC) is one of the most frequent malignant neoplasms worldwide. Genetic polymorphism has been reported as a predictive factor related to a higher risk for HCC. Because the stromal cell-derived factor-1 (SDF-1) and its receptor, CXCR4, have been reported to play important roles in tumor cell proliferation, angiogenesis, and metastasis of HCC, the aim of this study was to estimate the relationship between SDF-1 and CXCR4 gene variants to HCC risk and clinicopathological status. Methods: Polymerase chain reaction-restriction fragment length polymorphism was used to measure SDF-1 (rs1801157) and CXCR4 (rs2228014) gene polymorphisms in 311 healthy controls and 102 patients with HCC. Results: Compared to controls, individuals with at least one A allele had a higher risk of 1.57-fold (95% CI: 1.00-2.47) to induce HCC and had a risk of 2.81-fold (95% CI: 1.04-7.58) to develop a status of stage III or stage IV disease, after being adjusted for other confounders. However, there was no significant association between CXCR4 gene polymorphism and either HCC risk or pathological status. Additionally, both gene polymorphisms were not associated with the serum expression of liver-related clinical pathological markers. Conclusions: SDF-1-3′A gene polymorphism could be considered as a factor related to an increased susceptibility to the risk and pathological development of HCC.

Original languageEnglish
Pages (from-to)412-418
Number of pages7
JournalClinical Chemistry and Laboratory Medicine
Volume47
Issue number4
DOIs
Publication statusPublished - Apr 1 2009
Externally publishedYes

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CXCR4 Receptors
Chemokine CXCL12
Polymorphism
Hepatocellular Carcinoma
Genes
Polymerase chain reaction
Cell proliferation
Liver
Tumors
Genetic Polymorphisms
Restriction Fragment Length Polymorphisms
Neoplasms
Biomarkers
Alleles
Cell Proliferation
Neoplasm Metastasis
Polymerase Chain Reaction

Keywords

  • CXCR4
  • Hepatocellular carcinoma (HCC)
  • Single nucleotide polymorphism (SNP)
  • Stromal cell-derived factor-1 (SDF-1)

ASJC Scopus subject areas

  • Clinical Biochemistry
  • Biochemistry, medical

Cite this

Stromal cell-derived factor-1 but not its receptor, CXCR4, gene variants increase susceptibility and pathological development of hepatocellular carcinoma. / Chang, Chi Chung; Chen, Shu Chen; Hsieh, Yi Hsien; Chen, Yi Chen; Chen, Tzy Yen; Chu, Yin Hung; Ma, Hui Jen; Chou, Ming Chih; Tsai, Hsiu Ting; Yang, Shun Fa.

In: Clinical Chemistry and Laboratory Medicine, Vol. 47, No. 4, 01.04.2009, p. 412-418.

Research output: Contribution to journalArticle

Chang, Chi Chung ; Chen, Shu Chen ; Hsieh, Yi Hsien ; Chen, Yi Chen ; Chen, Tzy Yen ; Chu, Yin Hung ; Ma, Hui Jen ; Chou, Ming Chih ; Tsai, Hsiu Ting ; Yang, Shun Fa. / Stromal cell-derived factor-1 but not its receptor, CXCR4, gene variants increase susceptibility and pathological development of hepatocellular carcinoma. In: Clinical Chemistry and Laboratory Medicine. 2009 ; Vol. 47, No. 4. pp. 412-418.
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AU - Chang, Chi Chung

AU - Chen, Shu Chen

AU - Hsieh, Yi Hsien

AU - Chen, Yi Chen

AU - Chen, Tzy Yen

AU - Chu, Yin Hung

AU - Ma, Hui Jen

AU - Chou, Ming Chih

AU - Tsai, Hsiu Ting

AU - Yang, Shun Fa

PY - 2009/4/1

Y1 - 2009/4/1

N2 - Background: Hepatocellular carcinoma (HCC) is one of the most frequent malignant neoplasms worldwide. Genetic polymorphism has been reported as a predictive factor related to a higher risk for HCC. Because the stromal cell-derived factor-1 (SDF-1) and its receptor, CXCR4, have been reported to play important roles in tumor cell proliferation, angiogenesis, and metastasis of HCC, the aim of this study was to estimate the relationship between SDF-1 and CXCR4 gene variants to HCC risk and clinicopathological status. Methods: Polymerase chain reaction-restriction fragment length polymorphism was used to measure SDF-1 (rs1801157) and CXCR4 (rs2228014) gene polymorphisms in 311 healthy controls and 102 patients with HCC. Results: Compared to controls, individuals with at least one A allele had a higher risk of 1.57-fold (95% CI: 1.00-2.47) to induce HCC and had a risk of 2.81-fold (95% CI: 1.04-7.58) to develop a status of stage III or stage IV disease, after being adjusted for other confounders. However, there was no significant association between CXCR4 gene polymorphism and either HCC risk or pathological status. Additionally, both gene polymorphisms were not associated with the serum expression of liver-related clinical pathological markers. Conclusions: SDF-1-3′A gene polymorphism could be considered as a factor related to an increased susceptibility to the risk and pathological development of HCC.

AB - Background: Hepatocellular carcinoma (HCC) is one of the most frequent malignant neoplasms worldwide. Genetic polymorphism has been reported as a predictive factor related to a higher risk for HCC. Because the stromal cell-derived factor-1 (SDF-1) and its receptor, CXCR4, have been reported to play important roles in tumor cell proliferation, angiogenesis, and metastasis of HCC, the aim of this study was to estimate the relationship between SDF-1 and CXCR4 gene variants to HCC risk and clinicopathological status. Methods: Polymerase chain reaction-restriction fragment length polymorphism was used to measure SDF-1 (rs1801157) and CXCR4 (rs2228014) gene polymorphisms in 311 healthy controls and 102 patients with HCC. Results: Compared to controls, individuals with at least one A allele had a higher risk of 1.57-fold (95% CI: 1.00-2.47) to induce HCC and had a risk of 2.81-fold (95% CI: 1.04-7.58) to develop a status of stage III or stage IV disease, after being adjusted for other confounders. However, there was no significant association between CXCR4 gene polymorphism and either HCC risk or pathological status. Additionally, both gene polymorphisms were not associated with the serum expression of liver-related clinical pathological markers. Conclusions: SDF-1-3′A gene polymorphism could be considered as a factor related to an increased susceptibility to the risk and pathological development of HCC.

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