Stroke rehabilitation is associated with a reduction in dementia risk: A population-based retrospective cohort study

Yi Chun Chou, Chien Chang Liao, Li Ting Su, Pei Yu Yang, Fung Chang Sung

Research output: Contribution to journalArticle

18 Citations (Scopus)

Abstract

Objective: Focusing on the relationship between physical activity and incident cognitive impairment, the aim of this study was to investigate whether stroke rehabilitation reduces the risk of dementia. Methods: Claims data of 1,000,000 insured subjects randomly selected from the National Health Insurance programme of Taiwan were used to identify adults with a newly diagnosed ischaemic stroke in 1997-2002. Among them, 1,375 received rehabilitation and 3,722 did not. Both groups were followed up until the end of 2007 to measure the incidence of development of dementia. Results: The incidence of development of dementia was lower in the rehabilitation cohort than in the non-rehabilitation cohort (1.22 vs 1.70 per 100 person-years), with an adjusted hazard ratio (HR) of 0.73 (95% confidence interval (CI) = 0.60-0.89) in the multivariate Cox proportional hazard regression analysis. Female gender (HR = 1.26, 95% CI = 1.07-1.50), older age (HR = 7.71, 95% CI = 3.36-17.7), low income (HR = 1.82, 95% CI = 1.42-2.33), and Parkinson's disease (HR = 1.64, 95% CI = 1.33-2.03) were risk factors associated with the development of dementia. Conclusion: Post-stroke rehabilitation is associated with a reduction in dementia risk among ischaemic stroke patients.

Original languageEnglish
Pages (from-to)319-324
Number of pages6
JournalJournal of Rehabilitation Medicine
Volume44
Issue number4
DOIs
Publication statusPublished - Apr 2012

Fingerprint

Dementia
Cohort Studies
Retrospective Studies
Confidence Intervals
Population
National Health Programs
Rehabilitation
Stroke
Incidence
Taiwan
Parkinson Disease
Regression Analysis
Stroke Rehabilitation
Exercise

Keywords

  • Cohort study
  • Comorbidity
  • Dementia
  • Rehabilitation
  • Stroke

ASJC Scopus subject areas

  • Rehabilitation
  • Physical Therapy, Sports Therapy and Rehabilitation
  • Medicine(all)

Cite this

Stroke rehabilitation is associated with a reduction in dementia risk : A population-based retrospective cohort study. / Chou, Yi Chun; Liao, Chien Chang; Su, Li Ting; Yang, Pei Yu; Sung, Fung Chang.

In: Journal of Rehabilitation Medicine, Vol. 44, No. 4, 04.2012, p. 319-324.

Research output: Contribution to journalArticle

@article{b96363c683a7429b9d8c77f02bb6e162,
title = "Stroke rehabilitation is associated with a reduction in dementia risk: A population-based retrospective cohort study",
abstract = "Objective: Focusing on the relationship between physical activity and incident cognitive impairment, the aim of this study was to investigate whether stroke rehabilitation reduces the risk of dementia. Methods: Claims data of 1,000,000 insured subjects randomly selected from the National Health Insurance programme of Taiwan were used to identify adults with a newly diagnosed ischaemic stroke in 1997-2002. Among them, 1,375 received rehabilitation and 3,722 did not. Both groups were followed up until the end of 2007 to measure the incidence of development of dementia. Results: The incidence of development of dementia was lower in the rehabilitation cohort than in the non-rehabilitation cohort (1.22 vs 1.70 per 100 person-years), with an adjusted hazard ratio (HR) of 0.73 (95{\%} confidence interval (CI) = 0.60-0.89) in the multivariate Cox proportional hazard regression analysis. Female gender (HR = 1.26, 95{\%} CI = 1.07-1.50), older age (HR = 7.71, 95{\%} CI = 3.36-17.7), low income (HR = 1.82, 95{\%} CI = 1.42-2.33), and Parkinson's disease (HR = 1.64, 95{\%} CI = 1.33-2.03) were risk factors associated with the development of dementia. Conclusion: Post-stroke rehabilitation is associated with a reduction in dementia risk among ischaemic stroke patients.",
keywords = "Cohort study, Comorbidity, Dementia, Rehabilitation, Stroke",
author = "Chou, {Yi Chun} and Liao, {Chien Chang} and Su, {Li Ting} and Yang, {Pei Yu} and Sung, {Fung Chang}",
year = "2012",
month = "4",
doi = "10.2340/16501977-0935",
language = "English",
volume = "44",
pages = "319--324",
journal = "Journal of Rehabilitation Medicine",
issn = "1650-1977",
publisher = "Foundation for Rehabilitation Information",
number = "4",

}

TY - JOUR

T1 - Stroke rehabilitation is associated with a reduction in dementia risk

T2 - A population-based retrospective cohort study

AU - Chou, Yi Chun

AU - Liao, Chien Chang

AU - Su, Li Ting

AU - Yang, Pei Yu

AU - Sung, Fung Chang

PY - 2012/4

Y1 - 2012/4

N2 - Objective: Focusing on the relationship between physical activity and incident cognitive impairment, the aim of this study was to investigate whether stroke rehabilitation reduces the risk of dementia. Methods: Claims data of 1,000,000 insured subjects randomly selected from the National Health Insurance programme of Taiwan were used to identify adults with a newly diagnosed ischaemic stroke in 1997-2002. Among them, 1,375 received rehabilitation and 3,722 did not. Both groups were followed up until the end of 2007 to measure the incidence of development of dementia. Results: The incidence of development of dementia was lower in the rehabilitation cohort than in the non-rehabilitation cohort (1.22 vs 1.70 per 100 person-years), with an adjusted hazard ratio (HR) of 0.73 (95% confidence interval (CI) = 0.60-0.89) in the multivariate Cox proportional hazard regression analysis. Female gender (HR = 1.26, 95% CI = 1.07-1.50), older age (HR = 7.71, 95% CI = 3.36-17.7), low income (HR = 1.82, 95% CI = 1.42-2.33), and Parkinson's disease (HR = 1.64, 95% CI = 1.33-2.03) were risk factors associated with the development of dementia. Conclusion: Post-stroke rehabilitation is associated with a reduction in dementia risk among ischaemic stroke patients.

AB - Objective: Focusing on the relationship between physical activity and incident cognitive impairment, the aim of this study was to investigate whether stroke rehabilitation reduces the risk of dementia. Methods: Claims data of 1,000,000 insured subjects randomly selected from the National Health Insurance programme of Taiwan were used to identify adults with a newly diagnosed ischaemic stroke in 1997-2002. Among them, 1,375 received rehabilitation and 3,722 did not. Both groups were followed up until the end of 2007 to measure the incidence of development of dementia. Results: The incidence of development of dementia was lower in the rehabilitation cohort than in the non-rehabilitation cohort (1.22 vs 1.70 per 100 person-years), with an adjusted hazard ratio (HR) of 0.73 (95% confidence interval (CI) = 0.60-0.89) in the multivariate Cox proportional hazard regression analysis. Female gender (HR = 1.26, 95% CI = 1.07-1.50), older age (HR = 7.71, 95% CI = 3.36-17.7), low income (HR = 1.82, 95% CI = 1.42-2.33), and Parkinson's disease (HR = 1.64, 95% CI = 1.33-2.03) were risk factors associated with the development of dementia. Conclusion: Post-stroke rehabilitation is associated with a reduction in dementia risk among ischaemic stroke patients.

KW - Cohort study

KW - Comorbidity

KW - Dementia

KW - Rehabilitation

KW - Stroke

UR - http://www.scopus.com/inward/record.url?scp=84859911460&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84859911460&partnerID=8YFLogxK

U2 - 10.2340/16501977-0935

DO - 10.2340/16501977-0935

M3 - Article

C2 - 22366821

AN - SCOPUS:84859911460

VL - 44

SP - 319

EP - 324

JO - Journal of Rehabilitation Medicine

JF - Journal of Rehabilitation Medicine

SN - 1650-1977

IS - 4

ER -