Strategies to Preclude Hepatitis C Virus Entry

Thierry Pierre Robert Burnouf; Ching Hsuan Liu; Liang-Tzung Lin

doi:10.5772/65470

Strategies to Preclude Hepatitis C Virus Entry

Thierry Pierre Robert Burnouf, Ching Hsuan Liu, Liang-Tzung Lin

Research output: Chapter in Book/Report/Conference proceeding › Chapter

Abstract

Without a preventive vaccine, hepatitis C virus (HCV) remains an important pathogen worldwide with millions of carriers at risk of end-stage liver diseases. Despite the introduction of novel direct-acting antivirals (DAAs), resistance problems, challenges with the difficult-to-treat populations and high costs limit the widespread application of these drugs. Antivirals with alternative mechanism(s) of action, such as by restricting viral entry or cell-to-cell spread, could help expand the scope of antiviral strategies for the management of hepatitis C. Transfusion-associated HCV infection remains another issue in endemic and resource-limited areas around the world. This chapter describes some of the latest developments in antiviral strategies to preclude HCV entry, such as through monoclonal antibodies and small molecules, as well as measures to enhance the safety of therapeutic plasma products in blood transfusion.

Original language	English
Title of host publication	Advances in Treatment of Hepatitis C and B
Publisher	InTech
ISBN (Electronic)	978-953-51-2994-3
ISBN (Print)	978-953-51-2993-6
DOIs	https://doi.org/10.5772/65470
Publication status	Published - Mar 8 2017

Keywords

hepatitis C virus
viral entry
antivirals
entry inhibitors
monoclonal antibodies
small molecules
therapeutic plasma products

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10.5772/65470

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abstract = "Without a preventive vaccine, hepatitis C virus (HCV) remains an important pathogen worldwide with millions of carriers at risk of end-stage liver diseases. Despite the introduction of novel direct-acting antivirals (DAAs), resistance problems, challenges with the difficult-to-treat populations and high costs limit the widespread application of these drugs. Antivirals with alternative mechanism(s) of action, such as by restricting viral entry or cell-to-cell spread, could help expand the scope of antiviral strategies for the management of hepatitis C. Transfusion-associated HCV infection remains another issue in endemic and resource-limited areas around the world. This chapter describes some of the latest developments in antiviral strategies to preclude HCV entry, such as through monoclonal antibodies and small molecules, as well as measures to enhance the safety of therapeutic plasma products in blood transfusion.",

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