Strategies for improving diabetic therapy via alternative administration routes that involve stimuli-responsive insulin-delivering systems

Yu Jung Lin, Fwu Long Mi, Po Yen Lin, Yang Bao Miao, Tringyo Huang, Kuan Hung Chen, Chiung Tong Chen, Yen Chang, Hsing Wen Sung

Research output: Contribution to journalArticle

7 Citations (Scopus)


The encapsulation of insulin in micro- or nanodelivery systems may eliminate the need for frequent subcutaneous injections, improving the quality of life of diabetic patients. Formulations for oral, intranasal, pulmonary, subcutaneous, and transdermal administration have been developed. The use of stimuli-responsive polymeric carriers that can release the encapsulated drug in response to changes of the environmental stimuli or external activation enables the design of less invasive or non-invasive systems for smart insulin delivery from depots in the body. This article will look at strategies for the development of responsive delivery systems and the future meeting of the demands of new modes of insulin delivery.

Original languageEnglish
JournalAdvanced Drug Delivery Reviews
Publication statusAccepted/In press - Jan 1 2018



  • Alternative routes
  • Diabetes mellitus
  • Glucose sensing
  • Insulin delivery
  • Stimuli-responsiveness

ASJC Scopus subject areas

  • Pharmaceutical Science

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