Straightforward access to biocompatible poly(2-oxazoline)-coated nanomaterials by polymerization-induced self-assembly

Dao Le, Friederike Wagner, Masanari Takamiya, I-Lun Hsiao, Gabriela Gil Alvaradejo, Uwe Strähle, Carsten Weiss, Guillaume Delaittre

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

We report the synthesis of poly(2-ethyl-2-oxazoline)-based (PEtOx) nanoobjects by polymerization-induced self-assembly (PISA). First, well-defined PEtOx macromolecular chain transfer agents were synthesized by cationic ring-opening polymerization and click chemistry. The photoinitiated PISA of 2-hydroxypropyl methacrylate mediated by these PEtOx produced nanoobjects spanning the full range of core-shell morphologies. The nanoparticles exhibited high biocompatibility and stealth properties in vitro or in vivo, as well as thermoresponsive behavior.

Original languageEnglish
JournalChemical Communications
DOIs
Publication statusE-pub ahead of print - Mar 12 2019

Fingerprint

Nanostructured materials
Self assembly
Polymerization
Cationic polymerization
Ring opening polymerization
Biocompatibility
Nanoparticles
poly(2-oxazoline)
poly(2-ethyl-2-oxazoline)
2-hydroxypropyl methacrylate

Cite this

Straightforward access to biocompatible poly(2-oxazoline)-coated nanomaterials by polymerization-induced self-assembly. / Le, Dao; Wagner, Friederike; Takamiya, Masanari; Hsiao, I-Lun; Gil Alvaradejo, Gabriela; Strähle, Uwe; Weiss, Carsten; Delaittre, Guillaume.

In: Chemical Communications, 12.03.2019.

Research output: Contribution to journalArticle

Le, Dao ; Wagner, Friederike ; Takamiya, Masanari ; Hsiao, I-Lun ; Gil Alvaradejo, Gabriela ; Strähle, Uwe ; Weiss, Carsten ; Delaittre, Guillaume. / Straightforward access to biocompatible poly(2-oxazoline)-coated nanomaterials by polymerization-induced self-assembly. In: Chemical Communications. 2019.
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AU - Weiss, Carsten

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