Store-operated calcium channels and pro-inflammatory signals

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11 Citations (Scopus)

Abstract

In non-excitable cells such as T lymphocytes, hepatocytes, mast cells, endothelia and epithelia, the major pathway for calcium (Ca2+) entry is through store-operated Ca2+ channels in the plasma membrane. These channels are activated by the emptying of intracellular Ca2+ stores, however, neither the gating mechanism nor the downstream targets of these channels has been clear established. Here, I review some of the proposed gating mechanisms of store-operated Ca2+ channels and the functional implications in regulating pro-inflammatory signals.

Original languageEnglish
Pages (from-to)813-820
Number of pages8
JournalActa Pharmacologica Sinica
Volume27
Issue number7
DOIs
Publication statusPublished - Jul 2006
Externally publishedYes

Keywords

  • Calcium channels
  • Calcium signaling
  • Capacitative Ca entry
  • Mast cells
  • Store-operated Ca entry

ASJC Scopus subject areas

  • Chemistry(all)
  • Pharmacology

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