Stimulatory effect of dopamine on acid secretion from the isolated rat stomach

Li Hsueh Tsai, Juei Tang Cheng

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

The effect of dopamine (DA) on acid secretion was studied using the everted preparation of isolated rat stomachs. DA concentrations, measured by HPLC-ECD in the rumen, corpus and antrum were 1.06 nmol/mg protein, 0.49 nmol/mg protein and 2.92 nmol/mg protein, respectively. DA stimulated acid secretion at a concentration of 10 nM and elicited the maximum response at 10 μM, which was at a level approximately 1.56-fold that of the spontaneous secretion but only about half that of secretion induced by histamine at a concentration of 0.3 mM. The concentration-dependent stimulation by DA was antagonized by octopamine and SCH 23390. Failure of proglumide and cimetidine to affect this stimulation ruled out the participation of histamine and/or gastrin. Scopolamine and tetrodotoxin completely inhibited the acid secretion induced by low concentrations of DA but inhibited only partially the response induced by high concentrations of DA. The results obtained indicate that DA induces acid secretion via activation of the dopamine D1 receptor, located on the cholinergic neurons and on some nonneuronal cells, in the rat stomach.

Original languageEnglish
Pages (from-to)235-240
Number of pages6
JournalNeuroscience Research
Volume21
Issue number3
DOIs
Publication statusPublished - 1995

Keywords

  • Acid secretion
  • Cholinergic neuron
  • Cimetidine
  • Dopamine
  • Isolated rat stomach
  • Octopamine
  • Proglumide
  • SCH 23390

ASJC Scopus subject areas

  • Neuroscience(all)

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