Stimulation of prostaglandin cyclooxygenase and prostacyclin synthetase activities by estradiol in rat aortic smooth muscle cells

Chang Wen-Chang, Nakao Junko, Orimo Hajime, Murota Sei-Itsu

Research output: Contribution to journalArticle

112 Citations (Scopus)

Abstract

The effects of estradiol on the arachidonic acid pool and prostacyclin biosynthetic activity in rat aortic smooth muscle cells were studied. Estradiol has no significant effect on the distribution of [14C] arachidonic acid in cells with respect to prostacyclin production assay, the endogenous fatty acid (specifically, arachidonic acid) composition of cellular phospholipid fractions and cellular phospholipase (or/and lipase) activities. However, estradiol significantly stimulates both prostaglandin cyclooxygenase and prostacyclin synthetase activities of cells, and induction of new protein biosynthesis is involved in the effect of estradiol on the stimulation of prostacyclin biosynthetic activity.

Original languageEnglish
Pages (from-to)472-482
Number of pages11
JournalBiochimica et Biophysica Acta - Lipids and Lipid Metabolism
Volume620
Issue number3
DOIs
Publication statusPublished - Dec 5 1980
Externally publishedYes

Keywords

  • (Rat aortic smooth muscle cell)
  • Atherosclerosis
  • Estradiol
  • Prostacyclin synthetase
  • Prostaglandin cyclooxygenase

ASJC Scopus subject areas

  • Biochemistry
  • Biophysics
  • Endocrinology
  • Medicine(all)

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