We report a girl with acute lymphoblastic leukemia who developed severe conjugated hyperbilirubinemia (total bilirubin 34.32 mg/dl, direct bilirubin 26.94 mg/dl) following gram-negative (Escherichia coli ) sepsis. Despite broad-spectrum antibiotics, her hyperbilirubinemia progressed. Her mental status deteriorated and steroid therapy (hydrocortisone 8 mg/kg/d) was initiated. Her condition then recovered rapidly. Based on our findings, we suggest that steroid may help to treat progressive conjugated hyperbilirubinemia due to gram-negative sepsis.
|Number of pages||3|
|Journal||Acta Paediatrica Sinica|
|Publication status||Published - 2007|
- Escherichia coli Infections/complications
- Hydrocortisone/therapeutic use
- Hyperbilirubinemia/drug therapy
- Parenteral Nutrition, Total