Steroid use in sepsis-induced conjugated hyperbilirubinemia

Report of one case

Jinn Li Wang, Tsong Yih Ou, Chun Nan Chen, Ein Yiao Shen

Research output: Contribution to journalArticle

Abstract

We report a girl with acute lymphoblastic leukemia who developed severe conjugated hyperbilirubinemia (total bilirubin 34.32 mg/dl, direct bilirubin 26.94 mg/dl) following gram-negative (Escherichia coli) sepsis. Despite broad-spectrum antibiotics, her hyperbilirubinemia progressed. Her mental status deteriorated and steroid therapy (hydrocortisone 8 mg/kg/d) was initiated. Her condition then recovered rapidly. Based on our findings, we suggest that steroid may help to treat progressive conjugated hyperbilirubinemia due to gram-negative sepsis.

Original languageEnglish
JournalActa Paediatrica Taiwanica
Volume48
Issue number3
Publication statusPublished - May 2007

Fingerprint

Hyperbilirubinemia
Sepsis
Steroids
Bilirubin
Precursor Cell Lymphoblastic Leukemia-Lymphoma
Hydrocortisone
Escherichia coli
Anti-Bacterial Agents
Therapeutics

Keywords

  • Hyperbilirubinemia
  • Sepsis
  • Steroid

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health

Cite this

Wang, J. L., Ou, T. Y., Chen, C. N., & Shen, E. Y. (2007). Steroid use in sepsis-induced conjugated hyperbilirubinemia: Report of one case. Acta Paediatrica Taiwanica, 48(3).

Steroid use in sepsis-induced conjugated hyperbilirubinemia : Report of one case. / Wang, Jinn Li; Ou, Tsong Yih; Chen, Chun Nan; Shen, Ein Yiao.

In: Acta Paediatrica Taiwanica, Vol. 48, No. 3, 05.2007.

Research output: Contribution to journalArticle

Wang, Jinn Li ; Ou, Tsong Yih ; Chen, Chun Nan ; Shen, Ein Yiao. / Steroid use in sepsis-induced conjugated hyperbilirubinemia : Report of one case. In: Acta Paediatrica Taiwanica. 2007 ; Vol. 48, No. 3.
@article{9e7d68874e0e463ebd54d38a99e56861,
title = "Steroid use in sepsis-induced conjugated hyperbilirubinemia: Report of one case",
abstract = "We report a girl with acute lymphoblastic leukemia who developed severe conjugated hyperbilirubinemia (total bilirubin 34.32 mg/dl, direct bilirubin 26.94 mg/dl) following gram-negative (Escherichia coli) sepsis. Despite broad-spectrum antibiotics, her hyperbilirubinemia progressed. Her mental status deteriorated and steroid therapy (hydrocortisone 8 mg/kg/d) was initiated. Her condition then recovered rapidly. Based on our findings, we suggest that steroid may help to treat progressive conjugated hyperbilirubinemia due to gram-negative sepsis.",
keywords = "Hyperbilirubinemia, Sepsis, Steroid",
author = "Wang, {Jinn Li} and Ou, {Tsong Yih} and Chen, {Chun Nan} and Shen, {Ein Yiao}",
year = "2007",
month = "5",
language = "English",
volume = "48",
journal = "Pediatrics and Neonatology",
issn = "1875-9572",
publisher = "臺灣兒科醫學會",
number = "3",

}

TY - JOUR

T1 - Steroid use in sepsis-induced conjugated hyperbilirubinemia

T2 - Report of one case

AU - Wang, Jinn Li

AU - Ou, Tsong Yih

AU - Chen, Chun Nan

AU - Shen, Ein Yiao

PY - 2007/5

Y1 - 2007/5

N2 - We report a girl with acute lymphoblastic leukemia who developed severe conjugated hyperbilirubinemia (total bilirubin 34.32 mg/dl, direct bilirubin 26.94 mg/dl) following gram-negative (Escherichia coli) sepsis. Despite broad-spectrum antibiotics, her hyperbilirubinemia progressed. Her mental status deteriorated and steroid therapy (hydrocortisone 8 mg/kg/d) was initiated. Her condition then recovered rapidly. Based on our findings, we suggest that steroid may help to treat progressive conjugated hyperbilirubinemia due to gram-negative sepsis.

AB - We report a girl with acute lymphoblastic leukemia who developed severe conjugated hyperbilirubinemia (total bilirubin 34.32 mg/dl, direct bilirubin 26.94 mg/dl) following gram-negative (Escherichia coli) sepsis. Despite broad-spectrum antibiotics, her hyperbilirubinemia progressed. Her mental status deteriorated and steroid therapy (hydrocortisone 8 mg/kg/d) was initiated. Her condition then recovered rapidly. Based on our findings, we suggest that steroid may help to treat progressive conjugated hyperbilirubinemia due to gram-negative sepsis.

KW - Hyperbilirubinemia

KW - Sepsis

KW - Steroid

UR - http://www.scopus.com/inward/record.url?scp=34548811919&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=34548811919&partnerID=8YFLogxK

M3 - Article

VL - 48

JO - Pediatrics and Neonatology

JF - Pediatrics and Neonatology

SN - 1875-9572

IS - 3

ER -