Stellate transformation of invasive trophoblast

A distinct phenotype of trophoblast that is involved in decidual vascular remodelling and controlled invasion during pregnancy

J. C. Shih, C. L. Chien, H. N. Ho, W. C. Lee, F. J. Hsieh

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

Background: Successful implantation relies on the tightly regulated invasion of extravillous trophoblasts (EVTs). However, little is known about their phenotypic differentiation and relevant motile behaviour. Furthermore, the cell-cell interactions between EVTs and decidual arterioles during physiological transformation are also poorly understood. Methods: A total of 128 decidual specimens from early and late gestations containing components of EVTs and spiral arterioles were investigated using immunohistochemistry and periodic acid-Schiff reaction. Results: Unipolar, tadpole-like EVTs are observed throughout the interstitial area, with a tendency to decrease along the invasive pathway. The stellate differentiation of the EVTs is identified around and inside decidual arterioles or in the third-trimester myometrium. Furthermore, stellate transformation of EVTs precedes its interactions with the decidual arteriole. These specialized stellate trophoblasts invade and infiltrate the tunica media, accompanying lacuna formation inside the vessel wall and perturbation of actin fibre alignment of the tunica media. Conclusion: Stellate transformation of trophoblasts may explain controlled invasion of EVTs and probably plays a key role in initiating cell-cell interaction in decidual vascular remodelling.

Original languageEnglish
Pages (from-to)1299-1304
Number of pages6
JournalHuman Reproduction
Volume21
Issue number5
DOIs
Publication statusPublished - Jan 1 2006
Externally publishedYes

Fingerprint

Physiologic Neovascularization
Keratin-7
Immunochemistry
Decidua
Trophoblasts
Arterioles
Keratins
Cell Communication
Cell Movement
Cell Differentiation
Phenotype
Pregnancy
Tunica Media
Periodic Acid-Schiff Reaction
Vascular Remodeling
Myometrium
Third Pregnancy Trimester
Larva
Actins
Immunohistochemistry

Keywords

  • Interstitial trophoblast
  • Pregnancy
  • Stellate transformation
  • Vascular remodelling

ASJC Scopus subject areas

  • Reproductive Medicine
  • Obstetrics and Gynaecology

Cite this

Stellate transformation of invasive trophoblast : A distinct phenotype of trophoblast that is involved in decidual vascular remodelling and controlled invasion during pregnancy. / Shih, J. C.; Chien, C. L.; Ho, H. N.; Lee, W. C.; Hsieh, F. J.

In: Human Reproduction, Vol. 21, No. 5, 01.01.2006, p. 1299-1304.

Research output: Contribution to journalArticle

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