Statin Use Is Associated with Bladder Pain Syndrome/Interstitial Cystitis: A Population-Based Case-Control Study

C. Y. Huang, S. D. Chung, L. T. Kao, H. C. Lin, L. H. Wang

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

Introduction: Statin may induce epithelial dysfunction of the bladder urothelium. Epithelial dysfunction was proposed as one of the major potential etiologies for bladder pain syndrome/interstitial cystitis (BPS/IC). In this study, we examined the association between statin use and BPS/IC using a population-based study. Subjects and Methods: This case-control study used the Taiwan Longitudinal Health Insurance Database. In total, 815 female subjects with BPS/IC and 4075 randomly selected female controls were included. We used a conditional logistic regression to compute the odds ratio (OR) for having previously used statins between cases and controls. Results: A conditional logistic regression analysis showed that the OR of prior statin users for cases was 1.52 (95% confidence interval (CI): 1.19-1.94) compared to controls after adjusting for diabetes, hypertension, coronary heart disease, obesity, chronic pelvic pain, irritable bowel syndrome, fibromyalgia, chronic fatigue syndrome, depression, panic disorder, migraines, sicca syndrome, allergies, endometriosis, and asthma. Furthermore, adjusted ORs of regular and irregular statin use for cases were 1.58 (95% CI: 1.20-2.08) and 1.53 (95% CI: 1.02-2.31), respectively, compared to controls. Conclusion: We concluded that there was an association between statin use and BPS/IC.

Original languageEnglish
Pages (from-to)227-232
Number of pages6
JournalUrologia Internationalis
Volume95
DOIs
Publication statusPublished - Sep 1 2015

Fingerprint

Interstitial Cystitis
Hydroxymethylglutaryl-CoA Reductase Inhibitors
Case-Control Studies
Urinary Bladder
Pain
Population
Confidence Intervals
Logistic Models
Odds Ratio
Urothelium
Chronic Fatigue Syndrome
Pelvic Pain
Irritable Bowel Syndrome
Panic Disorder
Sjogren's Syndrome
Endometriosis
Health Insurance
Migraine Disorders
Taiwan
Chronic Pain

Keywords

  • BPS/IC
  • Epidemiology
  • Interstitial cystitis
  • Statin
  • Urogenecology

ASJC Scopus subject areas

  • Urology

Cite this

Statin Use Is Associated with Bladder Pain Syndrome/Interstitial Cystitis : A Population-Based Case-Control Study. / Huang, C. Y.; Chung, S. D.; Kao, L. T.; Lin, H. C.; Wang, L. H.

In: Urologia Internationalis, Vol. 95, 01.09.2015, p. 227-232.

Research output: Contribution to journalArticle

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