Statin therapy is associated with reduced risk of peptic ulcer disease in the Taiwanese population

Chun Jung Lin, Wei Chih Liao, Yu An Chen, Hwai Jeng Lin, Chun Lung Feng, Cheng Li Lin, Ying Ju Lin, Min Chuan Kao, Mei Zi Huang, Chih Ho Lai, Chia Hung Kao

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

Although statin use may affect the severity of chronic gastritis and gastric cancer, no data exists about the relationship between statin therapy and risk of peptic ulcer disease (PUD) in patients. We investigated the effect of statin use and the incidence of PUD from the Taiwan National Health Insurance Research Database (NHIRD). A total of 35,194 patients records for medical claims were enrolled. We performed a population-based case-control analysis to compare the incidence of PUD in patients who were prescribed statins and that in patients who were not. In the univariate logistic analysis, we found that statin was not significant risk of PUD. However, a multivariate model indicates that satin use was significantly associated with a reduced risk of PUD (adjusted odds ratio [aOR] = 0.87, 95% CI = 0.82-0.93, P < 0.001). The cumulative defined daily dose (DDD) was analyzed. Patients who prescribed fluvastatin =280 DDD, atorvastatin =200 DDD, and pravastatin ≥130 DDD dramatically decreased risk for PUD (aOR = 0.58, 0.67, and 0.71; 95% CI = 0.46-0.74, 0.57-0.78, and 0.56-0.91, respectively). Our results showed that statin therapy reduced the risk of PUD and this was associated with the high cumulative DDD of prescribed statins. This study reveals that active use of statins to be associated with decreased risk for PUD.

Original languageEnglish
Article number210
JournalFrontiers in Pharmacology
Volume8
Issue numberAPR
DOIs
Publication statusPublished - Apr 28 2017

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Hydroxymethylglutaryl-CoA Reductase Inhibitors
Peptic Ulcer
Population
fluvastatin
Therapeutics
Odds Ratio
Pravastatin
Incidence
National Health Programs
Gastritis
Taiwan
Stomach Neoplasms
Medical Records
Databases

Keywords

  • Case-control study
  • Cholesterol
  • Peptic ulcer disease
  • Statin

ASJC Scopus subject areas

  • Pharmacology
  • Pharmacology (medical)

Cite this

Statin therapy is associated with reduced risk of peptic ulcer disease in the Taiwanese population. / Lin, Chun Jung; Liao, Wei Chih; Chen, Yu An; Lin, Hwai Jeng; Feng, Chun Lung; Lin, Cheng Li; Lin, Ying Ju; Kao, Min Chuan; Huang, Mei Zi; Lai, Chih Ho; Kao, Chia Hung.

In: Frontiers in Pharmacology, Vol. 8, No. APR, 210, 28.04.2017.

Research output: Contribution to journalArticle

Lin, CJ, Liao, WC, Chen, YA, Lin, HJ, Feng, CL, Lin, CL, Lin, YJ, Kao, MC, Huang, MZ, Lai, CH & Kao, CH 2017, 'Statin therapy is associated with reduced risk of peptic ulcer disease in the Taiwanese population', Frontiers in Pharmacology, vol. 8, no. APR, 210. https://doi.org/10.3389/fphar.2017.00210
Lin, Chun Jung ; Liao, Wei Chih ; Chen, Yu An ; Lin, Hwai Jeng ; Feng, Chun Lung ; Lin, Cheng Li ; Lin, Ying Ju ; Kao, Min Chuan ; Huang, Mei Zi ; Lai, Chih Ho ; Kao, Chia Hung. / Statin therapy is associated with reduced risk of peptic ulcer disease in the Taiwanese population. In: Frontiers in Pharmacology. 2017 ; Vol. 8, No. APR.
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AU - Feng, Chun Lung

AU - Lin, Cheng Li

AU - Lin, Ying Ju

AU - Kao, Min Chuan

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AU - Lai, Chih Ho

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AB - Although statin use may affect the severity of chronic gastritis and gastric cancer, no data exists about the relationship between statin therapy and risk of peptic ulcer disease (PUD) in patients. We investigated the effect of statin use and the incidence of PUD from the Taiwan National Health Insurance Research Database (NHIRD). A total of 35,194 patients records for medical claims were enrolled. We performed a population-based case-control analysis to compare the incidence of PUD in patients who were prescribed statins and that in patients who were not. In the univariate logistic analysis, we found that statin was not significant risk of PUD. However, a multivariate model indicates that satin use was significantly associated with a reduced risk of PUD (adjusted odds ratio [aOR] = 0.87, 95% CI = 0.82-0.93, P < 0.001). The cumulative defined daily dose (DDD) was analyzed. Patients who prescribed fluvastatin =280 DDD, atorvastatin =200 DDD, and pravastatin ≥130 DDD dramatically decreased risk for PUD (aOR = 0.58, 0.67, and 0.71; 95% CI = 0.46-0.74, 0.57-0.78, and 0.56-0.91, respectively). Our results showed that statin therapy reduced the risk of PUD and this was associated with the high cumulative DDD of prescribed statins. This study reveals that active use of statins to be associated with decreased risk for PUD.

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