Static magnetic field attenuates mortality rate of mice by increasing the production of IL-1 receptor antagonist

Shu Li Lin, Wei Jen Chang, Yung Sheng Lin, Keng Liang Ou, Che Tong Lin, Chih Ping Lin, Haw Ming Huang

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

Purposes: Disseminated intravascular coagulation (DIC) is a complex systemic thrombohemorrhagic disorder involving intravascular coagulation and hemorrhage. The aim of this study is to test whether static magnetic field (SMF) is effective in attenuating lipopolysaccharide (LPS)-induced DIC. Materials and methods: In vivo experiments were performed in this study using male BALB/cByJ mice. An intraperitoneal injection of 50 mg/kg LPS was shown to lead to approximately 50% mortality and this dose was used in subsequent experiments. To test the effects of SMF on the survival rate of LPS-induced animals, the mice were exposed to 0.25-T SMF for 2h before LPS injection. In addition, the effect of a 2-h SMF treatment on the production of anti-inflammatory cytokines was evaluated. Results: In the first set of experiments, we found that the survival rate was higher in the SMF-exposed group than in the sham-exposed group. The circulating platelet (PLT) counts in the SMF-exposed mice were significantly higher than in the unexposed animals. However, no significant changes in inflammatory cytokine, including tumour necrosis factor- (TNF-), interleukin-1 (IL-1), interleukin-6 (IL-6) and monocyte chemotactic protein 1 (MCP-1), in plasma were found after SMF treatment. The results from the second experiment showed that the plasma levels of interleukin-1 receptor antagonist (IL-1ra) were higher in the SMF-exposed group than in the sham group. Conclusions: Exposure to an SMF increases the plasma levels of IL-1ra. This effect may inhibit the reduction in PLT in plasma, resulting in prevention in LPS induced DIC.

Original languageEnglish
Pages (from-to)633-640
Number of pages8
JournalInternational Journal of Radiation Biology
Volume85
Issue number7
DOIs
Publication statusPublished - Jul 2009

Fingerprint

Interleukin-1 Receptors
Magnetic Fields
Mortality
Lipopolysaccharides
Disseminated Intravascular Coagulation
Survival Rate
Cytokines
Chemokine CCL2
Intraperitoneal Injections
Platelet Count
Interleukin-1
Interleukin-6
Anti-Inflammatory Agents
Blood Platelets
Tumor Necrosis Factor-alpha
Hemorrhage
Injections

Keywords

  • Disseminated intravascular coagulation
  • Lipopolysaccharide
  • Proinflammatory cytokine
  • Static magnetic field

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging
  • Radiological and Ultrasound Technology

Cite this

Static magnetic field attenuates mortality rate of mice by increasing the production of IL-1 receptor antagonist. / Lin, Shu Li; Chang, Wei Jen; Lin, Yung Sheng; Ou, Keng Liang; Lin, Che Tong; Lin, Chih Ping; Huang, Haw Ming.

In: International Journal of Radiation Biology, Vol. 85, No. 7, 07.2009, p. 633-640.

Research output: Contribution to journalArticle

Lin, Shu Li ; Chang, Wei Jen ; Lin, Yung Sheng ; Ou, Keng Liang ; Lin, Che Tong ; Lin, Chih Ping ; Huang, Haw Ming. / Static magnetic field attenuates mortality rate of mice by increasing the production of IL-1 receptor antagonist. In: International Journal of Radiation Biology. 2009 ; Vol. 85, No. 7. pp. 633-640.
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AU - Lin, Chih Ping

AU - Huang, Haw Ming

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