1 Citation (Scopus)

Abstract

Purpose: Previous studies demonstrated that static magnetic fields (SMF) were effective in down-regulating the expression of lipopolysaccharide (LPS)-induced inflammatory cytokines. The aim of this study was to provide histological evidence of SMF attenuating LPS-induced multiple organ failure (MOF). Materials and methods: In this study, BALB/cByJNarl (5 weeks, weighing 20-25 g) mice were chosen as test subjects. The tested animals were challenged with 50 mg/kg LPS after they were exposed to a continuous SMF for 2 h. The survival rate and pathological changes in lungs, kidneys, and livers of the LPS- challenged mice were examined with and without SMF treatment. In addition, the effects of SMF exposure on body temperature control of the LPS-challenged mice were monitored. Results: Our results showed that at 30 h the survival rate of LPS-challenged mice increased 3.6-fold (p <0.05). In addition, 6 h after LPS injection, the average body temperature of SMF-exposed mice was 1.07°C lower than that of unexposed animals. Tissue biopsies demonstrated that SMF exposure reduced damage to the lungs, livers, and kidneys in the LPS-challenged mice. Conclusions: SMF show potential as a viable prophylactic alternative for controlling LPS-induced MOF.

Original languageEnglish
Pages (from-to)135-141
Number of pages7
JournalInternational Journal of Radiation Biology
Volume91
Issue number2
DOIs
Publication statusPublished - Feb 1 2015

Keywords

  • Histopathology
  • Lipopolysaccharide
  • Multiple organ failure
  • Static magnetic field

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging
  • Radiological and Ultrasound Technology
  • Medicine(all)

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