Static and dynamic characteristics of cerebral blood flow during the resting state

Qihong Zou, Changwei W. Wu, Elliot A. Stein, Yufeng Zang, Yihong Yang

Research output: Contribution to journalArticle

137 Citations (Scopus)

Abstract

In this study, the static and dynamic characteristics of cerebral blood flow (CBF) in the resting state were investigated using an arterial spin labeling (ASL) perfusion imaging technique. Consistent with previous PET results, static CBF measured by ASL was significantly higher in the posterior cingulate cortex (PCC), thalamus, insula/superior temporal gyrus (STG) and medial prefrontal cortex (MPFC) than the average CBF of the brain. The dynamic measurement of CBF fluctuations showed high correlation (functional connectivity) between components in the default mode network. These brain regions also had high local temporal synchrony and high fluctuation amplitude, as measured by regional homogeneity (ReHo) and amplitude of low-frequency fluctuation (ALFF) analyses. The spatial pattern of the static CBF correlated well with that of the dynamic indices. The high static and dynamic activities in the PCC, MPFC, insula/STG and thalamus suggest that these regions play a vital role in maintaining and facilitating fundamental brain functions.

Original languageEnglish
Pages (from-to)515-524
Number of pages10
JournalNeuroImage
Volume48
Issue number3
DOIs
Publication statusPublished - Nov 15 2009
Externally publishedYes

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Cerebrovascular Circulation
Gyrus Cinguli
Temporal Lobe
Prefrontal Cortex
Thalamus
Brain
Perfusion Imaging

Keywords

  • ALFF
  • CBF
  • Dynamic
  • Functional connectivity
  • ReHo
  • Resting state
  • Static

ASJC Scopus subject areas

  • Neurology
  • Cognitive Neuroscience

Cite this

Static and dynamic characteristics of cerebral blood flow during the resting state. / Zou, Qihong; Wu, Changwei W.; Stein, Elliot A.; Zang, Yufeng; Yang, Yihong.

In: NeuroImage, Vol. 48, No. 3, 15.11.2009, p. 515-524.

Research output: Contribution to journalArticle

Zou, Qihong ; Wu, Changwei W. ; Stein, Elliot A. ; Zang, Yufeng ; Yang, Yihong. / Static and dynamic characteristics of cerebral blood flow during the resting state. In: NeuroImage. 2009 ; Vol. 48, No. 3. pp. 515-524.
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