State-of-the-Art on Viral microRNAs in HPV Infection and Cancer Development

Palmiro Poltronieri, Binlian Sun, Kai Yao Huang, Tzu Hao Chang, Tzong Yi Lee

Research output: Contribution to journalReview article

2 Citations (Scopus)

Abstract

BACKGROUND: High-risk HPV subtypes are driving forces for human cancer development: HPV-16 and HPV-18 are responsible for most HPV-caused cancers. OBJECTIVE: This review describes the present knowledge on HR-HPV genomes coding potential for viral miRNAs. METHODS: HPV subtypes miRNA database, VIRmiRtar, has been constructed applying bioinformatics and a computational method, ViralMir, exploiting structural features, the presence of hairpins, and validation by comparison with RNA sequencing datasets. RESULTS: Several miRNA candidates have been localised in the genomes of high-risk HPV subtypes. Among these, HPV-16 miR-1, miR-2 and miR-3. The database contains a list of host candidate gene targets that may be responsible for the oncogenesis in the various cellular environments. CONCLUSION: miRNA silencing therapies, based on specific cellular uptake of miRNA mimics and antagomiRs, directed towards HPV encoded miRNAs and/or microRNAs deregulated in the host cells, could be a valuable approach to support pharmaceutical interventions in the treatment of HPV dependent cancers.

Original languageEnglish
Pages (from-to)85-91
Number of pages7
JournalMicroRNA (Shariqah, United Arab Emirates)
Volume7
Issue number2
DOIs
Publication statusPublished - Jan 1 2018

Fingerprint

MicroRNAs
Infection
Neoplasms
Human papillomavirus 16
Genome
Databases
RNA Sequence Analysis
Human papillomavirus 18
Human Development
Computational Biology
Carcinogenesis
Pharmaceutical Preparations
Genes

Keywords

  • Human Papilloma Virus (HPV)
  • immunity
  • microRNAs
  • oncogenesis
  • seed sequence complementarity
  • translation repression.

ASJC Scopus subject areas

  • Medicine(all)

Cite this

State-of-the-Art on Viral microRNAs in HPV Infection and Cancer Development. / Poltronieri, Palmiro; Sun, Binlian; Huang, Kai Yao; Chang, Tzu Hao; Lee, Tzong Yi.

In: MicroRNA (Shariqah, United Arab Emirates), Vol. 7, No. 2, 01.01.2018, p. 85-91.

Research output: Contribution to journalReview article

Poltronieri, Palmiro ; Sun, Binlian ; Huang, Kai Yao ; Chang, Tzu Hao ; Lee, Tzong Yi. / State-of-the-Art on Viral microRNAs in HPV Infection and Cancer Development. In: MicroRNA (Shariqah, United Arab Emirates). 2018 ; Vol. 7, No. 2. pp. 85-91.
@article{e00a0f0cb55240d1b662593c0dd9b5eb,
title = "State-of-the-Art on Viral microRNAs in HPV Infection and Cancer Development",
abstract = "BACKGROUND: High-risk HPV subtypes are driving forces for human cancer development: HPV-16 and HPV-18 are responsible for most HPV-caused cancers. OBJECTIVE: This review describes the present knowledge on HR-HPV genomes coding potential for viral miRNAs. METHODS: HPV subtypes miRNA database, VIRmiRtar, has been constructed applying bioinformatics and a computational method, ViralMir, exploiting structural features, the presence of hairpins, and validation by comparison with RNA sequencing datasets. RESULTS: Several miRNA candidates have been localised in the genomes of high-risk HPV subtypes. Among these, HPV-16 miR-1, miR-2 and miR-3. The database contains a list of host candidate gene targets that may be responsible for the oncogenesis in the various cellular environments. CONCLUSION: miRNA silencing therapies, based on specific cellular uptake of miRNA mimics and antagomiRs, directed towards HPV encoded miRNAs and/or microRNAs deregulated in the host cells, could be a valuable approach to support pharmaceutical interventions in the treatment of HPV dependent cancers.",
keywords = "Human Papilloma Virus (HPV), immunity, microRNAs, oncogenesis, seed sequence complementarity, translation repression.",
author = "Palmiro Poltronieri and Binlian Sun and Huang, {Kai Yao} and Chang, {Tzu Hao} and Lee, {Tzong Yi}",
year = "2018",
month = "1",
day = "1",
doi = "10.2174/2211536607666180328115155",
language = "English",
volume = "7",
pages = "85--91",
journal = "MicroRNA (Shariqah, United Arab Emirates)",
issn = "2211-5366",
publisher = "Bentham Science Publishers",
number = "2",

}

TY - JOUR

T1 - State-of-the-Art on Viral microRNAs in HPV Infection and Cancer Development

AU - Poltronieri, Palmiro

AU - Sun, Binlian

AU - Huang, Kai Yao

AU - Chang, Tzu Hao

AU - Lee, Tzong Yi

PY - 2018/1/1

Y1 - 2018/1/1

N2 - BACKGROUND: High-risk HPV subtypes are driving forces for human cancer development: HPV-16 and HPV-18 are responsible for most HPV-caused cancers. OBJECTIVE: This review describes the present knowledge on HR-HPV genomes coding potential for viral miRNAs. METHODS: HPV subtypes miRNA database, VIRmiRtar, has been constructed applying bioinformatics and a computational method, ViralMir, exploiting structural features, the presence of hairpins, and validation by comparison with RNA sequencing datasets. RESULTS: Several miRNA candidates have been localised in the genomes of high-risk HPV subtypes. Among these, HPV-16 miR-1, miR-2 and miR-3. The database contains a list of host candidate gene targets that may be responsible for the oncogenesis in the various cellular environments. CONCLUSION: miRNA silencing therapies, based on specific cellular uptake of miRNA mimics and antagomiRs, directed towards HPV encoded miRNAs and/or microRNAs deregulated in the host cells, could be a valuable approach to support pharmaceutical interventions in the treatment of HPV dependent cancers.

AB - BACKGROUND: High-risk HPV subtypes are driving forces for human cancer development: HPV-16 and HPV-18 are responsible for most HPV-caused cancers. OBJECTIVE: This review describes the present knowledge on HR-HPV genomes coding potential for viral miRNAs. METHODS: HPV subtypes miRNA database, VIRmiRtar, has been constructed applying bioinformatics and a computational method, ViralMir, exploiting structural features, the presence of hairpins, and validation by comparison with RNA sequencing datasets. RESULTS: Several miRNA candidates have been localised in the genomes of high-risk HPV subtypes. Among these, HPV-16 miR-1, miR-2 and miR-3. The database contains a list of host candidate gene targets that may be responsible for the oncogenesis in the various cellular environments. CONCLUSION: miRNA silencing therapies, based on specific cellular uptake of miRNA mimics and antagomiRs, directed towards HPV encoded miRNAs and/or microRNAs deregulated in the host cells, could be a valuable approach to support pharmaceutical interventions in the treatment of HPV dependent cancers.

KW - Human Papilloma Virus (HPV)

KW - immunity

KW - microRNAs

KW - oncogenesis

KW - seed sequence complementarity

KW - translation repression.

UR - http://www.scopus.com/inward/record.url?scp=85055901715&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85055901715&partnerID=8YFLogxK

U2 - 10.2174/2211536607666180328115155

DO - 10.2174/2211536607666180328115155

M3 - Review article

C2 - 29595120

AN - SCOPUS:85055901715

VL - 7

SP - 85

EP - 91

JO - MicroRNA (Shariqah, United Arab Emirates)

JF - MicroRNA (Shariqah, United Arab Emirates)

SN - 2211-5366

IS - 2

ER -