State-dependent amygdala stimulation-induced cardiovascular effects in rats

Ruei Jen Chiou, Chung Chih Kuo, Keng Chen Liang, Chen Tung Yen

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

Stimulation of the amygdala is known to produce pressor, depressor, or has no effects. The present study was performed to test whether amygdala cardiovascular effects are influenced by consciousness states and by different types of anesthetics. Adult rats were set up for stimulation amygdala and measurement of blood pressure in a chronic preparation. After recovery, same sites of the amygdala were stimulated electrically for several trials with the rat under conscious or anesthetic states induced by pentobarbital, urethane, ketamine, α-chloralose and urethane plus α-chloralose, respectively. The interval between any two stimulation trials was at least 2 days. The stimulation was an 80-Hz, 0.5-ms, 100-μA square wave pulse train lasting for 15 s. Cardiovascular responsive sites were found in the central, medial, and basolateral nuclei of the amygdala. In stimulating these responsive sites, significantly different cardiovascular effects were induced under a conscious state and an anesthetized state of the animal, yet no significant differences were found among the various anesthetic agents. We conclude, that the cardiovascular influence of the amygdala is state-dependent in the rat.

Original languageEnglish
Pages (from-to)432-440
Number of pages9
JournalChinese Journal of Physiology
Volume52
Issue number6
DOIs
Publication statusPublished - 2009

Fingerprint

Amygdala
Anesthetics
Chloralose
Urethane
Intralaminar Thalamic Nuclei
Ketamine
Pentobarbital
Consciousness
Blood Pressure

Keywords

  • Amygdala
  • Anesthesia
  • Blood pressure
  • Chloralose
  • Electrical stimulation
  • Heart rate
  • Ketamine
  • Pentobarbital
  • Urethane

ASJC Scopus subject areas

  • Physiology
  • Physiology (medical)

Cite this

State-dependent amygdala stimulation-induced cardiovascular effects in rats. / Chiou, Ruei Jen; Kuo, Chung Chih; Liang, Keng Chen; Yen, Chen Tung.

In: Chinese Journal of Physiology, Vol. 52, No. 6, 2009, p. 432-440.

Research output: Contribution to journalArticle

Chiou, Ruei Jen ; Kuo, Chung Chih ; Liang, Keng Chen ; Yen, Chen Tung. / State-dependent amygdala stimulation-induced cardiovascular effects in rats. In: Chinese Journal of Physiology. 2009 ; Vol. 52, No. 6. pp. 432-440.
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