Staphylococcus lugdunensis Infective Endocarditis: A Literature Review and Analysis of Risk Factors

Po Yen Liu, Yung Feng Huang, Chia Wan Tang, Ying Yao Chen, Kai Sheng Hsieh, Luo Ping Ger, Yao Shen Chen, Yung Ching Liu

Research output: Contribution to journalArticle

43 Citations (Scopus)

Abstract

Background/Purpose: Infective endocarditis caused by Staphylococcus lugdunensis is a rare disease. Since its first description in 1988, there have only been a few reports of this disease and the causative organism. These publications were primarily case reports and brief case series. We conducted a literature review to identify the nature of the disease and its risk factors. Methods: We retrospectively reviewed the cases reported between 1988 and 2008 by searching the relevant literature using the keywords "endocarditis" and "Staphylococcus lugdunensis" in the Medline database. All cases included met the definition of the modified Duke criteria. Results: For the period 1988-2008, 67 cases from 27 articles were reviewed. The mean age of individuals was 53.9 years. Left-sided valvular endocarditis represented 52 (82.5%) of cases and native-valve endocarditis was evident in 48 (78.7%) of cases. A large proportion (82%) of 50 S. lugdunensis strains were susceptible to penicillin. Valve replacement operations were performed in 42 (66.7%) patients and the mortality rate was 38.8%. Univariate analysis showed a higher mortality rate in patients aged more than 50 years, those treated before 1995, those treated with antibiotics alone, and those with growth not detected by echocar-diography. Medical treatment alone was the independent risk factor for mortality by multivariate analysis. Conclusion: S. lugdunensis endocarditis led to substantial morbidity and mortality. Detailed microbiological identification, echocardiography evaluation, and valve replacement may improve the clinical outcome of individuals with S. lugdunensis endocarditis.

Original languageEnglish
Pages (from-to)478-484
Number of pages7
JournalJournal of Microbiology, Immunology and Infection
Volume43
Issue number6
DOIs
Publication statusPublished - Dec 2010

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Staphylococcus lugdunensis
Endocarditis
Mortality
Rare Diseases
Penicillins
Echocardiography
Publications
Multivariate Analysis
Databases
Anti-Bacterial Agents
Morbidity
Growth

Keywords

  • Infective endocarditis
  • Risk factors
  • Staphylococcus lugdunensis

ASJC Scopus subject areas

  • Microbiology (medical)
  • Immunology and Allergy
  • Immunology and Microbiology(all)
  • Infectious Diseases

Cite this

Staphylococcus lugdunensis Infective Endocarditis : A Literature Review and Analysis of Risk Factors. / Liu, Po Yen; Huang, Yung Feng; Tang, Chia Wan; Chen, Ying Yao; Hsieh, Kai Sheng; Ger, Luo Ping; Chen, Yao Shen; Liu, Yung Ching.

In: Journal of Microbiology, Immunology and Infection, Vol. 43, No. 6, 12.2010, p. 478-484.

Research output: Contribution to journalArticle

Liu, Po Yen ; Huang, Yung Feng ; Tang, Chia Wan ; Chen, Ying Yao ; Hsieh, Kai Sheng ; Ger, Luo Ping ; Chen, Yao Shen ; Liu, Yung Ching. / Staphylococcus lugdunensis Infective Endocarditis : A Literature Review and Analysis of Risk Factors. In: Journal of Microbiology, Immunology and Infection. 2010 ; Vol. 43, No. 6. pp. 478-484.
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