Staging of untreated squamous cell carcinoma of buccal mucosa with 18F-FDG PET

Comparison with head and neck CT/MRI and histopathology

Tzu Chen Yen, Joseph Tung Chieh Chang, Shu Hang Ng, Yu Chen Chang, Sheng Chieh Chan, Hung Ming Wang, Lai Chu See, Tsung-Ming Chen, Chung Jan Kang, Yi Fen Wu, Kun Ju Lin, Chun Ta Liao

Research output: Contribution to journalArticle

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Abstract

This prospective, nonrandomized, case-control study evaluated the impact of 18F-FDG PET in staging untreated squamous cell carcinoma of the buccal mucosa (BSCC) and compared the results with CT/MRI and histopathology. Methods: Between January 2002 and April 2004, 102 untreated BSCC patients with cMO (no evidence of distant metastatic focus on chest radiograph, liver ultrasonograph, and bone scan) were enrolled with either conventional work-up (CWU, n = 51) or PET (CWU+PET, n = 51). All were monitored for at least 6 mo. The comparative diagnostic efficacies of PET and CT/MRI were evaluated using the area under the receiver-operating-characteristic curve (AUC). The primary endpoint was the percentage reduction in futile surgery (preoperative detection of distant metastatic lesions). The secondary endpoint was the 2-y cumulative recurrence rate among study participants (with PET) compared with that of comparable control subjects (without PET). Results: Significant benefits of PET compared with those of CT/MRI for BSCC patients were in the detection of locoregional (AUC, 0.973 vs. 0.928; P = 0.026), regional (AUC, 0.939 vs. 0.837; P = 0.026), and level II (AUC, 0.974 vs. 0.717; P = 0.02) lymph nodes. Two percent (1/51) of the patients experienced a reduction in futile surgery in the CWU+PET group compared with 0% (0/51) in the CWU group. However, no statistical difference was found in the 2-y locoregional control rate between the CWU and the CWU+PET groups. Conclusion: The role of 18F-FDG PET for BSCC with cMO is limited. Although PET is superior to CT/MRI in identifying cervical nodal metastases, it does not improve locoregional recurrence.

Original languageEnglish
Pages (from-to)775-781
Number of pages7
JournalJournal of Nuclear Medicine
Volume46
Issue number5
Publication statusPublished - Dec 1 2005
Externally publishedYes

Fingerprint

Fluorodeoxyglucose F18
Mouth Mucosa
Area Under Curve
Squamous Cell Carcinoma
Neck
Head
Recurrence
ROC Curve
Case-Control Studies
Thorax
Lymph Nodes
Neoplasm Metastasis
Bone and Bones
Liver

Keywords

  • F-FDG
  • Buccal mucosa
  • PET
  • Squamous cell carcinoma
  • Staging

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging

Cite this

Yen, T. C., Chang, J. T. C., Ng, S. H., Chang, Y. C., Chan, S. C., Wang, H. M., ... Liao, C. T. (2005). Staging of untreated squamous cell carcinoma of buccal mucosa with 18F-FDG PET: Comparison with head and neck CT/MRI and histopathology. Journal of Nuclear Medicine, 46(5), 775-781.

Staging of untreated squamous cell carcinoma of buccal mucosa with 18F-FDG PET : Comparison with head and neck CT/MRI and histopathology. / Yen, Tzu Chen; Chang, Joseph Tung Chieh; Ng, Shu Hang; Chang, Yu Chen; Chan, Sheng Chieh; Wang, Hung Ming; See, Lai Chu; Chen, Tsung-Ming; Kang, Chung Jan; Wu, Yi Fen; Lin, Kun Ju; Liao, Chun Ta.

In: Journal of Nuclear Medicine, Vol. 46, No. 5, 01.12.2005, p. 775-781.

Research output: Contribution to journalArticle

Yen, TC, Chang, JTC, Ng, SH, Chang, YC, Chan, SC, Wang, HM, See, LC, Chen, T-M, Kang, CJ, Wu, YF, Lin, KJ & Liao, CT 2005, 'Staging of untreated squamous cell carcinoma of buccal mucosa with 18F-FDG PET: Comparison with head and neck CT/MRI and histopathology', Journal of Nuclear Medicine, vol. 46, no. 5, pp. 775-781.
Yen, Tzu Chen ; Chang, Joseph Tung Chieh ; Ng, Shu Hang ; Chang, Yu Chen ; Chan, Sheng Chieh ; Wang, Hung Ming ; See, Lai Chu ; Chen, Tsung-Ming ; Kang, Chung Jan ; Wu, Yi Fen ; Lin, Kun Ju ; Liao, Chun Ta. / Staging of untreated squamous cell carcinoma of buccal mucosa with 18F-FDG PET : Comparison with head and neck CT/MRI and histopathology. In: Journal of Nuclear Medicine. 2005 ; Vol. 46, No. 5. pp. 775-781.
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abstract = "This prospective, nonrandomized, case-control study evaluated the impact of 18F-FDG PET in staging untreated squamous cell carcinoma of the buccal mucosa (BSCC) and compared the results with CT/MRI and histopathology. Methods: Between January 2002 and April 2004, 102 untreated BSCC patients with cMO (no evidence of distant metastatic focus on chest radiograph, liver ultrasonograph, and bone scan) were enrolled with either conventional work-up (CWU, n = 51) or PET (CWU+PET, n = 51). All were monitored for at least 6 mo. The comparative diagnostic efficacies of PET and CT/MRI were evaluated using the area under the receiver-operating-characteristic curve (AUC). The primary endpoint was the percentage reduction in futile surgery (preoperative detection of distant metastatic lesions). The secondary endpoint was the 2-y cumulative recurrence rate among study participants (with PET) compared with that of comparable control subjects (without PET). Results: Significant benefits of PET compared with those of CT/MRI for BSCC patients were in the detection of locoregional (AUC, 0.973 vs. 0.928; P = 0.026), regional (AUC, 0.939 vs. 0.837; P = 0.026), and level II (AUC, 0.974 vs. 0.717; P = 0.02) lymph nodes. Two percent (1/51) of the patients experienced a reduction in futile surgery in the CWU+PET group compared with 0{\%} (0/51) in the CWU group. However, no statistical difference was found in the 2-y locoregional control rate between the CWU and the CWU+PET groups. Conclusion: The role of 18F-FDG PET for BSCC with cMO is limited. Although PET is superior to CT/MRI in identifying cervical nodal metastases, it does not improve locoregional recurrence.",
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AU - Chang, Joseph Tung Chieh

AU - Ng, Shu Hang

AU - Chang, Yu Chen

AU - Chan, Sheng Chieh

AU - Wang, Hung Ming

AU - See, Lai Chu

AU - Chen, Tsung-Ming

AU - Kang, Chung Jan

AU - Wu, Yi Fen

AU - Lin, Kun Ju

AU - Liao, Chun Ta

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N2 - This prospective, nonrandomized, case-control study evaluated the impact of 18F-FDG PET in staging untreated squamous cell carcinoma of the buccal mucosa (BSCC) and compared the results with CT/MRI and histopathology. Methods: Between January 2002 and April 2004, 102 untreated BSCC patients with cMO (no evidence of distant metastatic focus on chest radiograph, liver ultrasonograph, and bone scan) were enrolled with either conventional work-up (CWU, n = 51) or PET (CWU+PET, n = 51). All were monitored for at least 6 mo. The comparative diagnostic efficacies of PET and CT/MRI were evaluated using the area under the receiver-operating-characteristic curve (AUC). The primary endpoint was the percentage reduction in futile surgery (preoperative detection of distant metastatic lesions). The secondary endpoint was the 2-y cumulative recurrence rate among study participants (with PET) compared with that of comparable control subjects (without PET). Results: Significant benefits of PET compared with those of CT/MRI for BSCC patients were in the detection of locoregional (AUC, 0.973 vs. 0.928; P = 0.026), regional (AUC, 0.939 vs. 0.837; P = 0.026), and level II (AUC, 0.974 vs. 0.717; P = 0.02) lymph nodes. Two percent (1/51) of the patients experienced a reduction in futile surgery in the CWU+PET group compared with 0% (0/51) in the CWU group. However, no statistical difference was found in the 2-y locoregional control rate between the CWU and the CWU+PET groups. Conclusion: The role of 18F-FDG PET for BSCC with cMO is limited. Although PET is superior to CT/MRI in identifying cervical nodal metastases, it does not improve locoregional recurrence.

AB - This prospective, nonrandomized, case-control study evaluated the impact of 18F-FDG PET in staging untreated squamous cell carcinoma of the buccal mucosa (BSCC) and compared the results with CT/MRI and histopathology. Methods: Between January 2002 and April 2004, 102 untreated BSCC patients with cMO (no evidence of distant metastatic focus on chest radiograph, liver ultrasonograph, and bone scan) were enrolled with either conventional work-up (CWU, n = 51) or PET (CWU+PET, n = 51). All were monitored for at least 6 mo. The comparative diagnostic efficacies of PET and CT/MRI were evaluated using the area under the receiver-operating-characteristic curve (AUC). The primary endpoint was the percentage reduction in futile surgery (preoperative detection of distant metastatic lesions). The secondary endpoint was the 2-y cumulative recurrence rate among study participants (with PET) compared with that of comparable control subjects (without PET). Results: Significant benefits of PET compared with those of CT/MRI for BSCC patients were in the detection of locoregional (AUC, 0.973 vs. 0.928; P = 0.026), regional (AUC, 0.939 vs. 0.837; P = 0.026), and level II (AUC, 0.974 vs. 0.717; P = 0.02) lymph nodes. Two percent (1/51) of the patients experienced a reduction in futile surgery in the CWU+PET group compared with 0% (0/51) in the CWU group. However, no statistical difference was found in the 2-y locoregional control rate between the CWU and the CWU+PET groups. Conclusion: The role of 18F-FDG PET for BSCC with cMO is limited. Although PET is superior to CT/MRI in identifying cervical nodal metastases, it does not improve locoregional recurrence.

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