Stage-specific Dietary Factors Associated with the Correa Multistep and Multifactorial Process of Human Gastric Carcinogenesis

Hui Yin Hsiung, Jean Ching Yuan Fann, Amy Ming Fang Yen, Sam Li Sheng Chen, Sherry Yueh Hsia Chiu, Tsung Ho Ku, Tzeng Ying Liu, Hsiu Hsi Chen, Ming Wei Lin

Research output: Contribution to journalArticle

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Abstract

We assessed how individual dietary intakes act at different points in the chain of sequential stage of the Correa model in an area of Taiwan with high incidence of gastric cancer (GC). Using data on 2,201 participants in a two-stage screening for gastric neoplasia with pepsinogen test, we identified 154 superficial gastritis (SG), 32 atrophic gastritis (AG), 117 intestinal metaplasia (IM), and 22 GC. Effects of individual item-based and construct-based dietary variables aggregated by factor analysis on each stage of gastric neoplasm were assessed. Based on 1,211 subjects with complete information on serological test and dietary questionnaire, SG was associated with positive quartile trend for the intake of meat (trend test P = 0.0014) and the intake of fruits and leafy vegetables (trend test P = 0.0177), but with the negative trend for the intake of shrimp sauce (trend test P = 0.039). A significant positive association was noted between milk and AG (trend test P = 0.014) and IM (P = 0.0087). A positive association between seafood and IM was noted (P = 0.011). Frequent leafy vegetable intake based on individual item was inversely associated with GC (P = 0.0084), whereas frequent intake of meat showed a high positive association (P

Original languageEnglish
Pages (from-to)1-13
Number of pages13
JournalNutrition and Cancer
DOIs
Publication statusAccepted/In press - Mar 31 2016

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Stomach Neoplasms
Stomach
Metaplasia
Carcinogenesis
Atrophic Gastritis
Gastritis
Vegetables
Meat
Pepsinogen A
Seafood
Serologic Tests
Taiwan
Statistical Factor Analysis
Fruit
Milk
Incidence
Neoplasms

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Nutrition and Dietetics
  • Oncology
  • Cancer Research

Cite this

Stage-specific Dietary Factors Associated with the Correa Multistep and Multifactorial Process of Human Gastric Carcinogenesis. / Hsiung, Hui Yin; Fann, Jean Ching Yuan; Yen, Amy Ming Fang; Chen, Sam Li Sheng; Chiu, Sherry Yueh Hsia; Ku, Tsung Ho; Liu, Tzeng Ying; Chen, Hsiu Hsi; Lin, Ming Wei.

In: Nutrition and Cancer, 31.03.2016, p. 1-13.

Research output: Contribution to journalArticle

Hsiung, Hui Yin ; Fann, Jean Ching Yuan ; Yen, Amy Ming Fang ; Chen, Sam Li Sheng ; Chiu, Sherry Yueh Hsia ; Ku, Tsung Ho ; Liu, Tzeng Ying ; Chen, Hsiu Hsi ; Lin, Ming Wei. / Stage-specific Dietary Factors Associated with the Correa Multistep and Multifactorial Process of Human Gastric Carcinogenesis. In: Nutrition and Cancer. 2016 ; pp. 1-13.
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