Spontaneous Echo Contrast in Internal Jugular Veins

A Probable Indicator for Systemic Inflammation and a Prothrombotic State

Hung Yi Hsu, Chih Ping Chung, Shu Yi Chen, Yi Ying Chiang, Han Hwa Hu

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

The hypothesis that spontaneous echo contrast (SEC) in the internal jugular vein (IJV) is a clinical indicator for systemic inflammation and thrombogenesis is investigated in this study. Fifty-two patients with cardiovascular diseases and 25 nondiseased subjects were evaluated. SEC was observed in 96 of 154 IJVs. The visual grading of SEC showed good interobserver agreement on SEC grades (κ value: 0.846, p < 0.001). Generalized estimating equations analysis was used for univariate and multivariate analysis. Univariate analysis showed that peak flow velocity in corresponding IJV (coefficient -0.001 [95% CI -0.019, -0.001], p = 0.031), jugular venous reflux (JVR, -0.010 [-0.019, -0.001], p = 0.002), plasma levels of fibrinogen (0.464 [0.208, 0.719], p < 0.001) and hs-C-reactive protein (hs-CRP) (0.479 [0.184, 0.774], p = 0.001) and previous history of ischemic stroke (0.779 [0.139, 1.417]; p = 0.017) correlated with the grades of SEC in IJV. Increased plasma levels of fibrinogen and hs-CRP, previous ischemic stroke, lower peak velocity in corresponding IJV and JVR were also independent predictors for the higher grades of SEC in IJV in multivariate regression analysis. SEC in IJV could be evaluated easily and semiquantitatively. SEC in IJVs could be a putative marker of cerebral circulation disturbance and an indicator of systemic inflammatory or prothrombotic state.

Original languageEnglish
Pages (from-to)926-932
Number of pages7
JournalUltrasound in Medicine and Biology
Volume38
Issue number6
DOIs
Publication statusPublished - Jun 1 2012
Externally publishedYes

Fingerprint

Jugular Veins
veins
echoes
Inflammation
fibrinogen
grade
C-Reactive Protein
Fibrinogen
Cerebrovascular Circulation
Multivariate Analysis
strokes
Stroke
proteins
Neck
Cardiovascular Diseases
Regression Analysis
markers
regression analysis
estimating
disturbances

Keywords

  • Fibrinogen
  • Ischemic stroke
  • Jugular vein
  • Spontaneous echo contrast

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging
  • Radiological and Ultrasound Technology
  • Biophysics

Cite this

Spontaneous Echo Contrast in Internal Jugular Veins : A Probable Indicator for Systemic Inflammation and a Prothrombotic State. / Hsu, Hung Yi; Chung, Chih Ping; Chen, Shu Yi; Chiang, Yi Ying; Hu, Han Hwa.

In: Ultrasound in Medicine and Biology, Vol. 38, No. 6, 01.06.2012, p. 926-932.

Research output: Contribution to journalArticle

@article{0c66707c55534119963d75c2296784c5,
title = "Spontaneous Echo Contrast in Internal Jugular Veins: A Probable Indicator for Systemic Inflammation and a Prothrombotic State",
abstract = "The hypothesis that spontaneous echo contrast (SEC) in the internal jugular vein (IJV) is a clinical indicator for systemic inflammation and thrombogenesis is investigated in this study. Fifty-two patients with cardiovascular diseases and 25 nondiseased subjects were evaluated. SEC was observed in 96 of 154 IJVs. The visual grading of SEC showed good interobserver agreement on SEC grades (κ value: 0.846, p < 0.001). Generalized estimating equations analysis was used for univariate and multivariate analysis. Univariate analysis showed that peak flow velocity in corresponding IJV (coefficient -0.001 [95{\%} CI -0.019, -0.001], p = 0.031), jugular venous reflux (JVR, -0.010 [-0.019, -0.001], p = 0.002), plasma levels of fibrinogen (0.464 [0.208, 0.719], p < 0.001) and hs-C-reactive protein (hs-CRP) (0.479 [0.184, 0.774], p = 0.001) and previous history of ischemic stroke (0.779 [0.139, 1.417]; p = 0.017) correlated with the grades of SEC in IJV. Increased plasma levels of fibrinogen and hs-CRP, previous ischemic stroke, lower peak velocity in corresponding IJV and JVR were also independent predictors for the higher grades of SEC in IJV in multivariate regression analysis. SEC in IJV could be evaluated easily and semiquantitatively. SEC in IJVs could be a putative marker of cerebral circulation disturbance and an indicator of systemic inflammatory or prothrombotic state.",
keywords = "Fibrinogen, Ischemic stroke, Jugular vein, Spontaneous echo contrast",
author = "Hsu, {Hung Yi} and Chung, {Chih Ping} and Chen, {Shu Yi} and Chiang, {Yi Ying} and Hu, {Han Hwa}",
year = "2012",
month = "6",
day = "1",
doi = "10.1016/j.ultrasmedbio.2012.02.003",
language = "English",
volume = "38",
pages = "926--932",
journal = "Ultrasound in Medicine and Biology",
issn = "0301-5629",
publisher = "Elsevier USA",
number = "6",

}

TY - JOUR

T1 - Spontaneous Echo Contrast in Internal Jugular Veins

T2 - A Probable Indicator for Systemic Inflammation and a Prothrombotic State

AU - Hsu, Hung Yi

AU - Chung, Chih Ping

AU - Chen, Shu Yi

AU - Chiang, Yi Ying

AU - Hu, Han Hwa

PY - 2012/6/1

Y1 - 2012/6/1

N2 - The hypothesis that spontaneous echo contrast (SEC) in the internal jugular vein (IJV) is a clinical indicator for systemic inflammation and thrombogenesis is investigated in this study. Fifty-two patients with cardiovascular diseases and 25 nondiseased subjects were evaluated. SEC was observed in 96 of 154 IJVs. The visual grading of SEC showed good interobserver agreement on SEC grades (κ value: 0.846, p < 0.001). Generalized estimating equations analysis was used for univariate and multivariate analysis. Univariate analysis showed that peak flow velocity in corresponding IJV (coefficient -0.001 [95% CI -0.019, -0.001], p = 0.031), jugular venous reflux (JVR, -0.010 [-0.019, -0.001], p = 0.002), plasma levels of fibrinogen (0.464 [0.208, 0.719], p < 0.001) and hs-C-reactive protein (hs-CRP) (0.479 [0.184, 0.774], p = 0.001) and previous history of ischemic stroke (0.779 [0.139, 1.417]; p = 0.017) correlated with the grades of SEC in IJV. Increased plasma levels of fibrinogen and hs-CRP, previous ischemic stroke, lower peak velocity in corresponding IJV and JVR were also independent predictors for the higher grades of SEC in IJV in multivariate regression analysis. SEC in IJV could be evaluated easily and semiquantitatively. SEC in IJVs could be a putative marker of cerebral circulation disturbance and an indicator of systemic inflammatory or prothrombotic state.

AB - The hypothesis that spontaneous echo contrast (SEC) in the internal jugular vein (IJV) is a clinical indicator for systemic inflammation and thrombogenesis is investigated in this study. Fifty-two patients with cardiovascular diseases and 25 nondiseased subjects were evaluated. SEC was observed in 96 of 154 IJVs. The visual grading of SEC showed good interobserver agreement on SEC grades (κ value: 0.846, p < 0.001). Generalized estimating equations analysis was used for univariate and multivariate analysis. Univariate analysis showed that peak flow velocity in corresponding IJV (coefficient -0.001 [95% CI -0.019, -0.001], p = 0.031), jugular venous reflux (JVR, -0.010 [-0.019, -0.001], p = 0.002), plasma levels of fibrinogen (0.464 [0.208, 0.719], p < 0.001) and hs-C-reactive protein (hs-CRP) (0.479 [0.184, 0.774], p = 0.001) and previous history of ischemic stroke (0.779 [0.139, 1.417]; p = 0.017) correlated with the grades of SEC in IJV. Increased plasma levels of fibrinogen and hs-CRP, previous ischemic stroke, lower peak velocity in corresponding IJV and JVR were also independent predictors for the higher grades of SEC in IJV in multivariate regression analysis. SEC in IJV could be evaluated easily and semiquantitatively. SEC in IJVs could be a putative marker of cerebral circulation disturbance and an indicator of systemic inflammatory or prothrombotic state.

KW - Fibrinogen

KW - Ischemic stroke

KW - Jugular vein

KW - Spontaneous echo contrast

UR - http://www.scopus.com/inward/record.url?scp=84860477905&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84860477905&partnerID=8YFLogxK

U2 - 10.1016/j.ultrasmedbio.2012.02.003

DO - 10.1016/j.ultrasmedbio.2012.02.003

M3 - Article

VL - 38

SP - 926

EP - 932

JO - Ultrasound in Medicine and Biology

JF - Ultrasound in Medicine and Biology

SN - 0301-5629

IS - 6

ER -