Spontaneous bacterial peritonitis in patients with hepatitis B-related cirrhosis and hepatocellular carcinoma

Sun Sang Wang, Yang Te Tsai, Shou Dong Lee, How Tshung Chen, Chi Wen Lu, Fa Yauh Lee, Jin Shiung Jeng, Yung Ching Liu, Kwang Juei Lo

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22 Citations (Scopus)


To delineate the natural clinical course of spontaneous bacterial peritonitis in hepatitis B-related cirrhosis and to determine if it occurs in hepatocellular carcinoma, a prospective survey was conducted in 262 patients over 2 1 2 years. The in-hospital incidence and mortality rates of spontaneous bacterial peritonitis were 21.6% and 36.4%, respectively, in cirrhosis and 7.3% and 50% in hepatocellular carcinoma. In cirrhosis, the cumulative probability of annual recurrence of spontaneous bacterial peritonitis was 47.3%, which was significantly higher than the annual probability of occurrence of 11.3% in those with no previous attack (P <0.0001). The cumulative probability of annual survival was 27.6% in the spontaneous bacterial peritonitis patients, significantly lower than the probability of 64.0% in the control group (P = 0.0001). A univariate analysis, with Kaplan-Meier curves compared by the Mantel-Cox test, and subsequent multivariate analysis by stepwise Cox regression procedure were used to evaluate 37 variables recorded immediately after admission. Blood urea nitrogen concentration 10.5 mmol/L urea (30 mg/dL) and ascitic fluid protein concentration

Original languageEnglish
Pages (from-to)1656-1662
Number of pages7
Issue number6
Publication statusPublished - 1991
Externally publishedYes

ASJC Scopus subject areas

  • Gastroenterology


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