Sponge-Derived 24-Homoscalaranes as Potent Anti-Inflammatory Agents

Bo Rong Peng; Kuei Hung Lai; Yu Chia Chang; You Ying Chen; Jui Hsin Su; Yusheng M. Huang; Po Jen Chen; Steve Sheng Fa Yu; Chang Yih Duh; Ping Jyun Sung

doi:10.3390/md18090434

Sponge-Derived 24-Homoscalaranes as Potent Anti-Inflammatory Agents

Bo Rong Peng, Kuei Hung Lai, Yu Chia Chang, You Ying Chen, Jui Hsin Su, Yusheng M. Huang, Po Jen Chen, Steve Sheng Fa Yu, Chang Yih Duh, Ping Jyun Sung

Graduate Institute of Pharmacognosy

Research output: Contribution to journal › Article › peer-review

6 Citations (Scopus)

Abstract

Scalarane-type sesterterpenoids are known for their therapeutic potential in cancer treatments. However, the anti-inflammatory properties of this class of metabolites remain elusive. Our current work aimed to investigate the anti-inflammatory scalaranes from marine sponge Lendenfeldia sp., resulting in the isolation of six new 24-homoscalaranes, lendenfeldaranes E-J (1-6). The structures of the new metabolites were determined by extensive spectroscopic analyses, and the absolute configuration of 1 was established by electronic circular dichroism (ECD) calculations. Compounds 2 and 3 were discovered to individually reduce the generation of superoxide anions, and compound 1 displayed an inhibitor effect on the release of elastase. These three compounds were proven to be the first anti-neutrophilic scalaranes.

Original language	English
Article number	434
Journal	Marine Drugs
Volume	18
Issue number	9
DOIs	https://doi.org/10.3390/md18090434
Publication status	Published - Aug 19 2020

Keywords

24-homoscalarane
anti-neutrophilic inflammation
elastase release
lendenfeldarane
Lendenfeldia
NADPH oxidase
sesterterpenoid
superoxide anion

ASJC Scopus subject areas

Drug Discovery

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.3390/md18090434

Cite this

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title = "Sponge-Derived 24-Homoscalaranes as Potent Anti-Inflammatory Agents",

abstract = "Scalarane-type sesterterpenoids are known for their therapeutic potential in cancer treatments. However, the anti-inflammatory properties of this class of metabolites remain elusive. Our current work aimed to investigate the anti-inflammatory scalaranes from marine sponge Lendenfeldia sp., resulting in the isolation of six new 24-homoscalaranes, lendenfeldaranes E-J (1-6). The structures of the new metabolites were determined by extensive spectroscopic analyses, and the absolute configuration of 1 was established by electronic circular dichroism (ECD) calculations. Compounds 2 and 3 were discovered to individually reduce the generation of superoxide anions, and compound 1 displayed an inhibitor effect on the release of elastase. These three compounds were proven to be the first anti-neutrophilic scalaranes.",

keywords = "24-homoscalarane, anti-neutrophilic inflammation, elastase release, lendenfeldarane, Lendenfeldia, NADPH oxidase, sesterterpenoid, superoxide anion",

author = "Peng, {Bo Rong} and Lai, {Kuei Hung} and Chang, {Yu Chia} and Chen, {You Ying} and Su, {Jui Hsin} and Huang, {Yusheng M.} and Chen, {Po Jen} and Yu, {Steve Sheng Fa} and Duh, {Chang Yih} and Sung, {Ping Jyun}",

note = "Funding Information: Acknowledgments: This work was mainly supported by grants from the National Museum of Marine Biology and Aquarium; and the Ministry of Science and Technology (Grant Nos MOST 106-2320-B-291-001-MY3, 107-2320-B-291-001-MY3, and 109-2320-B-291-001-MY3), Taiwan, awarded to P.-J.S. Funding Information: Funding: The research was founded by the Ministry of Science and Technology of Taiwan (MOST 106-2320-B-291-001-MY3, 107-2320-B-291-001-MY3, and 109-2320-B-291-001-MY3). Publisher Copyright: {\textcopyright} 2020 MDPI AG. All rights reserved.",

year = "2020",

month = aug,

day = "19",

doi = "10.3390/md18090434",

language = "English",

volume = "18",

journal = "Marine Drugs",

issn = "1660-3397",

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T1 - Sponge-Derived 24-Homoscalaranes as Potent Anti-Inflammatory Agents

AU - Peng, Bo Rong

AU - Lai, Kuei Hung

AU - Chang, Yu Chia

AU - Chen, You Ying

AU - Su, Jui Hsin

AU - Huang, Yusheng M.

AU - Chen, Po Jen

AU - Yu, Steve Sheng Fa

AU - Duh, Chang Yih

AU - Sung, Ping Jyun

N1 - Funding Information: Acknowledgments: This work was mainly supported by grants from the National Museum of Marine Biology and Aquarium; and the Ministry of Science and Technology (Grant Nos MOST 106-2320-B-291-001-MY3, 107-2320-B-291-001-MY3, and 109-2320-B-291-001-MY3), Taiwan, awarded to P.-J.S. Funding Information: Funding: The research was founded by the Ministry of Science and Technology of Taiwan (MOST 106-2320-B-291-001-MY3, 107-2320-B-291-001-MY3, and 109-2320-B-291-001-MY3). Publisher Copyright: © 2020 MDPI AG. All rights reserved.

PY - 2020/8/19

Y1 - 2020/8/19

N2 - Scalarane-type sesterterpenoids are known for their therapeutic potential in cancer treatments. However, the anti-inflammatory properties of this class of metabolites remain elusive. Our current work aimed to investigate the anti-inflammatory scalaranes from marine sponge Lendenfeldia sp., resulting in the isolation of six new 24-homoscalaranes, lendenfeldaranes E-J (1-6). The structures of the new metabolites were determined by extensive spectroscopic analyses, and the absolute configuration of 1 was established by electronic circular dichroism (ECD) calculations. Compounds 2 and 3 were discovered to individually reduce the generation of superoxide anions, and compound 1 displayed an inhibitor effect on the release of elastase. These three compounds were proven to be the first anti-neutrophilic scalaranes.

AB - Scalarane-type sesterterpenoids are known for their therapeutic potential in cancer treatments. However, the anti-inflammatory properties of this class of metabolites remain elusive. Our current work aimed to investigate the anti-inflammatory scalaranes from marine sponge Lendenfeldia sp., resulting in the isolation of six new 24-homoscalaranes, lendenfeldaranes E-J (1-6). The structures of the new metabolites were determined by extensive spectroscopic analyses, and the absolute configuration of 1 was established by electronic circular dichroism (ECD) calculations. Compounds 2 and 3 were discovered to individually reduce the generation of superoxide anions, and compound 1 displayed an inhibitor effect on the release of elastase. These three compounds were proven to be the first anti-neutrophilic scalaranes.

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KW - anti-neutrophilic inflammation

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KW - sesterterpenoid

KW - superoxide anion

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Sponge-Derived 24-Homoscalaranes as Potent Anti-Inflammatory Agents

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

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