Sponge-Derived 24-Homoscalaranes as Potent Anti-Inflammatory Agents

Bo Rong Peng, Kuei Hung Lai, Yu Chia Chang, You Ying Chen, Jui Hsin Su, Yusheng M. Huang, Po Jen Chen, Steve Sheng Fa Yu, Chang Yih Duh, Ping Jyun Sung

Research output: Contribution to journalArticlepeer-review

Abstract

Scalarane-type sesterterpenoids are known for their therapeutic potential in cancer treatments. However, the anti-inflammatory properties of this class of metabolites remain elusive. Our current work aimed to investigate the anti-inflammatory scalaranes from marine sponge Lendenfeldia sp., resulting in the isolation of six new 24-homoscalaranes, lendenfeldaranes E-J (1-6). The structures of the new metabolites were determined by extensive spectroscopic analyses, and the absolute configuration of 1 was established by electronic circular dichroism (ECD) calculations. Compounds 2 and 3 were discovered to individually reduce the generation of superoxide anions, and compound 1 displayed an inhibitor effect on the release of elastase. These three compounds were proven to be the first anti-neutrophilic scalaranes.

Original languageEnglish
JournalMarine Drugs
Volume18
Issue number9
DOIs
Publication statusPublished - Aug 19 2020

Keywords

  • 24-homoscalarane
  • anti-neutrophilic inflammation
  • elastase release
  • lendenfeldarane
  • Lendenfeldia
  • NADPH oxidase
  • sesterterpenoid
  • superoxide anion

ASJC Scopus subject areas

  • Drug Discovery

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