Spinal pelvic-urethra reflex potentiation

Hsien Yu Peng, Tzer Bin Lin

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Spinal reflex potentiation (SRP) in the pelvic-urethra reflex activity is a form of activity-dependent neural plasticity, presumed to be essential for urethra contraction resulting continence under physiological conditions and also to underlie the pelvic pain caused by pathology in the pelvic cavity. Studies have demonstrated that SRP could be induced by electrical shocks, bladder distension and activation of the lumbosacral (L6-S1) spinal glutamatergic NMDA and AMPA receptors. Conversely, blockage of glutamatergic receptors using selective antagonists either attenuated or abolished the established SRP. Electrical shocks on and nicotine microinjection into the pontine tegmentum area facilitated SRP induction, but intrathecal serotonin antagonists abolished electrical stimulation- and nicotine-induced facilitation on SRP. Finally, the induction of SRP is highly estrogen-dependent, because surgical ablation of menstruation diminished the SRP which is prevented by estradiol supplements, and SRP is more significant in proestrus (high estrogen but low progesterone) than in metestrus (both estrogen and progesterone are low) of the menstrual cycle. We propose that SRP is relevant to urine continence under physiological conditions, and pathological facilitation of SRP could result in pelvic pain.

Original languageEnglish
Pages (from-to)64-67
Number of pages4
JournalBioMedicine (Netherlands)
Volume2
Issue number2
DOIs
Publication statusPublished - Jun 2012
Externally publishedYes

Fingerprint

Urethra
Reflex
Estrogens
Nicotine
Progesterone
Serotonin Antagonists
AMPA Receptors
Pathology
Ablation
N-Methyl-D-Aspartate Receptors
Plasticity
Estradiol
Chemical activation
Pelvic Pain
Shock
Metestrus
Proestrus
Neuronal Plasticity
Menstruation
Microinjections

Keywords

  • Continence
  • Lower urinary tract
  • Pelvic nerve
  • Spinal cord
  • Urethra

ASJC Scopus subject areas

  • Medicine(all)
  • Biochemistry, Genetics and Molecular Biology(all)

Cite this

Spinal pelvic-urethra reflex potentiation. / Peng, Hsien Yu; Lin, Tzer Bin.

In: BioMedicine (Netherlands), Vol. 2, No. 2, 06.2012, p. 64-67.

Research output: Contribution to journalArticle

Peng, Hsien Yu ; Lin, Tzer Bin. / Spinal pelvic-urethra reflex potentiation. In: BioMedicine (Netherlands). 2012 ; Vol. 2, No. 2. pp. 64-67.
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