Spider angiomas in patients with liver cirrhosis

Role of vascular endothelial growth factor and basic fibroblast growth factor

Chung Pin Li, Fa Yauh Lee, Shinn Jang Hwang, Rei Hwa Lu, Wei Ping Lee, Yee Chao, Sung Sang Wang, Full Young Chang, Jacqueline Whang-Peng, Shou Dong Lee

Research output: Contribution to journalArticle

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Abstract

Aim: To investigate whether vascular endothelial growth factor (VEGF) and basic fibroblastic growth factor (bFGF) are associated with spider angiomas in patients with liver cirrhosis. Methods: Eighty-six patients with liver cirrhosis were enrolled and the number and size of the spider angiomas were recorded. Fifty-three healthy subjects were selected as controls. Plasma levels of VEGF and bFGF were measured in both the cirrhotics and the controls. Results: Plasma VEGF and bFGF were increased in cirrhotics compared with controls (122±13 vs. 71±11 pg/mL, P=0.003 for VEGF; 5.1±0.5 vs. 3.4±0.5 pg/mL, P=0.022 for bFGF). In cirrhotics, plasma VEGF and bFGF were also higher in patients with spider angiomas compared with patients without spider angiomas (185±28 vs. 90±10 pg/mL, P=0.003 for VEGF; 6.8±1.0 vs. 4.1±0.5 pg/mL, P=0.017 for bFGF). Multivariate logistic regression showed that young age and increased plasma levels of VEGF and bFGF were the most significant predictors for the presence of spider angiomas in cirrhotic patients (odds ratio [OR]=6.64, 95 % confidence interval [CI]=2.02-21.79, P=0.002; OR=4.35, 95 % CI=1.35-14.01, P=0.014; OR=5.66, 95 % CI=1.72-18.63, P=0.004, respectively). Conclusion: Plasma VEGF and bFGF are elevated in patients with liver cirrhosis. Age as well as plasma levels of VEGF and bFGF are significant predictors for spider angiomas in cirrhotic patients.

Original languageEnglish
Pages (from-to)2832-2835
Number of pages4
JournalWorld Journal of Gastroenterology
Volume9
Issue number12
Publication statusPublished - Dec 1 2003
Externally publishedYes

Fingerprint

Spiders
Fibroblast Growth Factor 2
Hemangioma
Liver Cirrhosis
Vascular Endothelial Growth Factor A
Intercellular Signaling Peptides and Proteins
Odds Ratio
Confidence Intervals
Healthy Volunteers
Logistic Models

ASJC Scopus subject areas

  • Gastroenterology

Cite this

Li, C. P., Lee, F. Y., Hwang, S. J., Lu, R. H., Lee, W. P., Chao, Y., ... Lee, S. D. (2003). Spider angiomas in patients with liver cirrhosis: Role of vascular endothelial growth factor and basic fibroblast growth factor. World Journal of Gastroenterology, 9(12), 2832-2835.

Spider angiomas in patients with liver cirrhosis : Role of vascular endothelial growth factor and basic fibroblast growth factor. / Li, Chung Pin; Lee, Fa Yauh; Hwang, Shinn Jang; Lu, Rei Hwa; Lee, Wei Ping; Chao, Yee; Wang, Sung Sang; Chang, Full Young; Whang-Peng, Jacqueline; Lee, Shou Dong.

In: World Journal of Gastroenterology, Vol. 9, No. 12, 01.12.2003, p. 2832-2835.

Research output: Contribution to journalArticle

Li, CP, Lee, FY, Hwang, SJ, Lu, RH, Lee, WP, Chao, Y, Wang, SS, Chang, FY, Whang-Peng, J & Lee, SD 2003, 'Spider angiomas in patients with liver cirrhosis: Role of vascular endothelial growth factor and basic fibroblast growth factor', World Journal of Gastroenterology, vol. 9, no. 12, pp. 2832-2835.
Li, Chung Pin ; Lee, Fa Yauh ; Hwang, Shinn Jang ; Lu, Rei Hwa ; Lee, Wei Ping ; Chao, Yee ; Wang, Sung Sang ; Chang, Full Young ; Whang-Peng, Jacqueline ; Lee, Shou Dong. / Spider angiomas in patients with liver cirrhosis : Role of vascular endothelial growth factor and basic fibroblast growth factor. In: World Journal of Gastroenterology. 2003 ; Vol. 9, No. 12. pp. 2832-2835.
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title = "Spider angiomas in patients with liver cirrhosis: Role of vascular endothelial growth factor and basic fibroblast growth factor",
abstract = "Aim: To investigate whether vascular endothelial growth factor (VEGF) and basic fibroblastic growth factor (bFGF) are associated with spider angiomas in patients with liver cirrhosis. Methods: Eighty-six patients with liver cirrhosis were enrolled and the number and size of the spider angiomas were recorded. Fifty-three healthy subjects were selected as controls. Plasma levels of VEGF and bFGF were measured in both the cirrhotics and the controls. Results: Plasma VEGF and bFGF were increased in cirrhotics compared with controls (122±13 vs. 71±11 pg/mL, P=0.003 for VEGF; 5.1±0.5 vs. 3.4±0.5 pg/mL, P=0.022 for bFGF). In cirrhotics, plasma VEGF and bFGF were also higher in patients with spider angiomas compared with patients without spider angiomas (185±28 vs. 90±10 pg/mL, P=0.003 for VEGF; 6.8±1.0 vs. 4.1±0.5 pg/mL, P=0.017 for bFGF). Multivariate logistic regression showed that young age and increased plasma levels of VEGF and bFGF were the most significant predictors for the presence of spider angiomas in cirrhotic patients (odds ratio [OR]=6.64, 95 {\%} confidence interval [CI]=2.02-21.79, P=0.002; OR=4.35, 95 {\%} CI=1.35-14.01, P=0.014; OR=5.66, 95 {\%} CI=1.72-18.63, P=0.004, respectively). Conclusion: Plasma VEGF and bFGF are elevated in patients with liver cirrhosis. Age as well as plasma levels of VEGF and bFGF are significant predictors for spider angiomas in cirrhotic patients.",
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T1 - Spider angiomas in patients with liver cirrhosis

T2 - Role of vascular endothelial growth factor and basic fibroblast growth factor

AU - Li, Chung Pin

AU - Lee, Fa Yauh

AU - Hwang, Shinn Jang

AU - Lu, Rei Hwa

AU - Lee, Wei Ping

AU - Chao, Yee

AU - Wang, Sung Sang

AU - Chang, Full Young

AU - Whang-Peng, Jacqueline

AU - Lee, Shou Dong

PY - 2003/12/1

Y1 - 2003/12/1

N2 - Aim: To investigate whether vascular endothelial growth factor (VEGF) and basic fibroblastic growth factor (bFGF) are associated with spider angiomas in patients with liver cirrhosis. Methods: Eighty-six patients with liver cirrhosis were enrolled and the number and size of the spider angiomas were recorded. Fifty-three healthy subjects were selected as controls. Plasma levels of VEGF and bFGF were measured in both the cirrhotics and the controls. Results: Plasma VEGF and bFGF were increased in cirrhotics compared with controls (122±13 vs. 71±11 pg/mL, P=0.003 for VEGF; 5.1±0.5 vs. 3.4±0.5 pg/mL, P=0.022 for bFGF). In cirrhotics, plasma VEGF and bFGF were also higher in patients with spider angiomas compared with patients without spider angiomas (185±28 vs. 90±10 pg/mL, P=0.003 for VEGF; 6.8±1.0 vs. 4.1±0.5 pg/mL, P=0.017 for bFGF). Multivariate logistic regression showed that young age and increased plasma levels of VEGF and bFGF were the most significant predictors for the presence of spider angiomas in cirrhotic patients (odds ratio [OR]=6.64, 95 % confidence interval [CI]=2.02-21.79, P=0.002; OR=4.35, 95 % CI=1.35-14.01, P=0.014; OR=5.66, 95 % CI=1.72-18.63, P=0.004, respectively). Conclusion: Plasma VEGF and bFGF are elevated in patients with liver cirrhosis. Age as well as plasma levels of VEGF and bFGF are significant predictors for spider angiomas in cirrhotic patients.

AB - Aim: To investigate whether vascular endothelial growth factor (VEGF) and basic fibroblastic growth factor (bFGF) are associated with spider angiomas in patients with liver cirrhosis. Methods: Eighty-six patients with liver cirrhosis were enrolled and the number and size of the spider angiomas were recorded. Fifty-three healthy subjects were selected as controls. Plasma levels of VEGF and bFGF were measured in both the cirrhotics and the controls. Results: Plasma VEGF and bFGF were increased in cirrhotics compared with controls (122±13 vs. 71±11 pg/mL, P=0.003 for VEGF; 5.1±0.5 vs. 3.4±0.5 pg/mL, P=0.022 for bFGF). In cirrhotics, plasma VEGF and bFGF were also higher in patients with spider angiomas compared with patients without spider angiomas (185±28 vs. 90±10 pg/mL, P=0.003 for VEGF; 6.8±1.0 vs. 4.1±0.5 pg/mL, P=0.017 for bFGF). Multivariate logistic regression showed that young age and increased plasma levels of VEGF and bFGF were the most significant predictors for the presence of spider angiomas in cirrhotic patients (odds ratio [OR]=6.64, 95 % confidence interval [CI]=2.02-21.79, P=0.002; OR=4.35, 95 % CI=1.35-14.01, P=0.014; OR=5.66, 95 % CI=1.72-18.63, P=0.004, respectively). Conclusion: Plasma VEGF and bFGF are elevated in patients with liver cirrhosis. Age as well as plasma levels of VEGF and bFGF are significant predictors for spider angiomas in cirrhotic patients.

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