Spectral localization of arbitrarily shaped regions of interest (SLASH) using single voxel signals

Zhiyue Wang, Ravinder Reddy, John C. Haselgrove, Cheng Yu Chen, Gadi Goelman, Robert A. Zimmerman, John S. Leigh

Research output: Contribution to journalArticle


A method for obtaining localized spectra from arbitrarily shaped regions of interest is described. When a sample consists of homogeneous compartments or domains, spectra localized in each compartment can be obtained from signals of single voxels with regular shapes by solving a set of simultaneous linear equations. Experimental demonstrations on a phantom and on human brain in vivo for a two compartment, two voxel case are presented. The issue of signal-to-noise ratio is also discussed.

Original languageEnglish
Pages (from-to)1203-1208
Number of pages6
JournalMagnetic Resonance Imaging
Issue number8
Publication statusPublished - 1993
Externally publishedYes



  • Arbitrary shape
  • Brain
  • Localization
  • Magnetic resonance spectroscopy

ASJC Scopus subject areas

  • Biophysics
  • Clinical Biochemistry
  • Structural Biology
  • Radiology Nuclear Medicine and imaging
  • Condensed Matter Physics

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