Spectral analysis of cerebrovascular regulation in patients with autonomic dysfunction

Chang Ming Chern, Terry B.J. Kuo, A. Ching Chao, Wen Yung Sheng, Han Hwa Hu

Research output: Contribution to journalArticle

Abstract

Background. Regulation of cerebral blood flow during orthostatic stress has been a major research topic in patients with orthostatic intolerance such as autonomic dysfunction. Spontaneous fluctuations of middle cerebral artery blood flow velocity (MCAFV) recorded with transcranial Doppler (TCD) have been found to contain information related to cerebrovascular regulation, which can be deciphered with spectral analysis. The purpose of this study was to evaluate the differences in cerebrovascular regulation between healthy volunteers and patients with autonomic dysfunction and orthostatic dizziness for using spectral analysis of MCAFV information derived from TCD during supine rest and orthostasis. Methods. Thirteen patients with autonomic dysfunction and orthostatic dizziness were found to have impaired cerebral autoregulation because of failure to maintain adequate cerebral blood flow velocity during a 30-minute head-up tilt study with concomitant TCD and cuff sphygomanometer monitoring. The data of bilateral MCAFV were compared between these 13 patients and 9 healthy volunteers using spectral analysis. Results. Spectral analysis of the MCAFV showed significantly decreased low frequency (LF) power in supine position in the patient group (p = 0.0002). In addition, the spectral power in the very low and low frequency (VLF & LF) ranges remained significantly lower in the patient group after tilting up (p < 0.05). Conclusions. (1). Our study results further support the previous findings that the LF component of the spontaneous fluctuations of MCAFV is important for cerebrovascular regulation. (2) The decreased LF MCAFV power may be a useful indicator or marker of impaired cerebrovascular regulation in patients with autonomic dysfunction.

Original languageEnglish
Pages (from-to)393-399
Number of pages7
JournalJournal of the Chinese Medical Association
Volume66
Issue number7
Publication statusPublished - Jul 1 2003
Externally publishedYes

Fingerprint

Cerebrovascular Circulation
Blood Flow Velocity
Middle Cerebral Artery
Dizziness
Healthy Volunteers
Orthostatic Intolerance
Supine Position
Homeostasis
Head

Keywords

  • Autonomic dysfunction
  • Cerebrosvascular regulation
  • Spectral analysis
  • Tilt table
  • Transcranial Doppler

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Spectral analysis of cerebrovascular regulation in patients with autonomic dysfunction. / Chern, Chang Ming; Kuo, Terry B.J.; Chao, A. Ching; Sheng, Wen Yung; Hu, Han Hwa.

In: Journal of the Chinese Medical Association, Vol. 66, No. 7, 01.07.2003, p. 393-399.

Research output: Contribution to journalArticle

@article{e5e926b1ebe747258b7d809cc108d3b6,
title = "Spectral analysis of cerebrovascular regulation in patients with autonomic dysfunction",
abstract = "Background. Regulation of cerebral blood flow during orthostatic stress has been a major research topic in patients with orthostatic intolerance such as autonomic dysfunction. Spontaneous fluctuations of middle cerebral artery blood flow velocity (MCAFV) recorded with transcranial Doppler (TCD) have been found to contain information related to cerebrovascular regulation, which can be deciphered with spectral analysis. The purpose of this study was to evaluate the differences in cerebrovascular regulation between healthy volunteers and patients with autonomic dysfunction and orthostatic dizziness for using spectral analysis of MCAFV information derived from TCD during supine rest and orthostasis. Methods. Thirteen patients with autonomic dysfunction and orthostatic dizziness were found to have impaired cerebral autoregulation because of failure to maintain adequate cerebral blood flow velocity during a 30-minute head-up tilt study with concomitant TCD and cuff sphygomanometer monitoring. The data of bilateral MCAFV were compared between these 13 patients and 9 healthy volunteers using spectral analysis. Results. Spectral analysis of the MCAFV showed significantly decreased low frequency (LF) power in supine position in the patient group (p = 0.0002). In addition, the spectral power in the very low and low frequency (VLF & LF) ranges remained significantly lower in the patient group after tilting up (p < 0.05). Conclusions. (1). Our study results further support the previous findings that the LF component of the spontaneous fluctuations of MCAFV is important for cerebrovascular regulation. (2) The decreased LF MCAFV power may be a useful indicator or marker of impaired cerebrovascular regulation in patients with autonomic dysfunction.",
keywords = "Autonomic dysfunction, Cerebrosvascular regulation, Spectral analysis, Tilt table, Transcranial Doppler",
author = "Chern, {Chang Ming} and Kuo, {Terry B.J.} and Chao, {A. Ching} and Sheng, {Wen Yung} and Hu, {Han Hwa}",
year = "2003",
month = "7",
day = "1",
language = "English",
volume = "66",
pages = "393--399",
journal = "Journal of the Chinese Medical Association",
issn = "1726-4901",
publisher = "Elsevier Taiwan LLC",
number = "7",

}

TY - JOUR

T1 - Spectral analysis of cerebrovascular regulation in patients with autonomic dysfunction

AU - Chern, Chang Ming

AU - Kuo, Terry B.J.

AU - Chao, A. Ching

AU - Sheng, Wen Yung

AU - Hu, Han Hwa

PY - 2003/7/1

Y1 - 2003/7/1

N2 - Background. Regulation of cerebral blood flow during orthostatic stress has been a major research topic in patients with orthostatic intolerance such as autonomic dysfunction. Spontaneous fluctuations of middle cerebral artery blood flow velocity (MCAFV) recorded with transcranial Doppler (TCD) have been found to contain information related to cerebrovascular regulation, which can be deciphered with spectral analysis. The purpose of this study was to evaluate the differences in cerebrovascular regulation between healthy volunteers and patients with autonomic dysfunction and orthostatic dizziness for using spectral analysis of MCAFV information derived from TCD during supine rest and orthostasis. Methods. Thirteen patients with autonomic dysfunction and orthostatic dizziness were found to have impaired cerebral autoregulation because of failure to maintain adequate cerebral blood flow velocity during a 30-minute head-up tilt study with concomitant TCD and cuff sphygomanometer monitoring. The data of bilateral MCAFV were compared between these 13 patients and 9 healthy volunteers using spectral analysis. Results. Spectral analysis of the MCAFV showed significantly decreased low frequency (LF) power in supine position in the patient group (p = 0.0002). In addition, the spectral power in the very low and low frequency (VLF & LF) ranges remained significantly lower in the patient group after tilting up (p < 0.05). Conclusions. (1). Our study results further support the previous findings that the LF component of the spontaneous fluctuations of MCAFV is important for cerebrovascular regulation. (2) The decreased LF MCAFV power may be a useful indicator or marker of impaired cerebrovascular regulation in patients with autonomic dysfunction.

AB - Background. Regulation of cerebral blood flow during orthostatic stress has been a major research topic in patients with orthostatic intolerance such as autonomic dysfunction. Spontaneous fluctuations of middle cerebral artery blood flow velocity (MCAFV) recorded with transcranial Doppler (TCD) have been found to contain information related to cerebrovascular regulation, which can be deciphered with spectral analysis. The purpose of this study was to evaluate the differences in cerebrovascular regulation between healthy volunteers and patients with autonomic dysfunction and orthostatic dizziness for using spectral analysis of MCAFV information derived from TCD during supine rest and orthostasis. Methods. Thirteen patients with autonomic dysfunction and orthostatic dizziness were found to have impaired cerebral autoregulation because of failure to maintain adequate cerebral blood flow velocity during a 30-minute head-up tilt study with concomitant TCD and cuff sphygomanometer monitoring. The data of bilateral MCAFV were compared between these 13 patients and 9 healthy volunteers using spectral analysis. Results. Spectral analysis of the MCAFV showed significantly decreased low frequency (LF) power in supine position in the patient group (p = 0.0002). In addition, the spectral power in the very low and low frequency (VLF & LF) ranges remained significantly lower in the patient group after tilting up (p < 0.05). Conclusions. (1). Our study results further support the previous findings that the LF component of the spontaneous fluctuations of MCAFV is important for cerebrovascular regulation. (2) The decreased LF MCAFV power may be a useful indicator or marker of impaired cerebrovascular regulation in patients with autonomic dysfunction.

KW - Autonomic dysfunction

KW - Cerebrosvascular regulation

KW - Spectral analysis

KW - Tilt table

KW - Transcranial Doppler

UR - http://www.scopus.com/inward/record.url?scp=0142027497&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0142027497&partnerID=8YFLogxK

M3 - Article

C2 - 14509400

AN - SCOPUS:0142027497

VL - 66

SP - 393

EP - 399

JO - Journal of the Chinese Medical Association

JF - Journal of the Chinese Medical Association

SN - 1726-4901

IS - 7

ER -