Spectral analysis of arterial blood pressure and cerebral blood flow velocity during supine rest and orthostasis

Chang Ming Chern, Terry Bo Jau Kuo, Wen Yung Sheng, Wen Jang Wong, Yung On Luk, Li Chi Hsu, Han Hwa Hu

Research output: Contribution to journalArticle

17 Citations (Scopus)

Abstract

This study evaluates the effect of orthostasis on the low frequency (LF, 0.04 to 0.15 Hz) fluctuations in the blood flow velocity of the middle cerebral artery (MCAFV) in relation to its arterial blood pressure (ABP) equivalent to further define and quantify this relationship in cerebrovascular regulation. Spectral analysis was performed on 22 healthy subjects during supine rest and head-up tilt. The power in the LF range can be used to quantify the LF fluctuations, and four types of LF power data could be obtained for each individual: LF power of supine MCAFV, LF power of supine ABP, LF power of tilt MCAFV, and LF power of tilt ABP. By comparing LF power of MCAFV with LF power of ABP, two power ratios could be generated to describe the flow-pressure relationship during supine rest and head-up tilt, respectively, supine power ratio (LF power of supine MCAFV/LF power of supine ABP) and tilt power ratio (LF power of flit MCAFV/LF power of tilt ABP). In addition, an index for dynamic autoregulation in response to orthostasis can be calculated from these two power ratios frill power ratio/supine power ratio). The authors found that this index was dependent on the extent of orthostatic MCAFV changes, and the dependency could be mathematically expressed (r = 0.61, P = .0001), suggesting its involvement in cerebrovascular regulation. Moreover, these data further support the previous observation that the LF fluctuations of MCAFV might result from modulation of its ABP equivalent, and the modulation effect could be quantified as the power ratio (LF power of MCAFV/LF power of ABP). These observations could be an important step toward further insight into cerebrovascular regulation, which warrants more research in the future.

Original languageEnglish
Pages (from-to)1136-1141
Number of pages6
JournalJournal of Cerebral Blood Flow and Metabolism
Volume19
Issue number10
Publication statusPublished - 1999
Externally publishedYes

Fingerprint

Cerebrovascular Circulation
Blood Flow Velocity
Dizziness
Arterial Pressure
Head
Middle Cerebral Artery
Healthy Volunteers
Homeostasis

Keywords

  • Arterial blood pressure
  • Cerebral blood flow
  • Head-up tilt
  • Spectral analysis
  • Transcranial Doppler sonography

ASJC Scopus subject areas

  • Neurology
  • Clinical Neurology
  • Cardiology and Cardiovascular Medicine

Cite this

Spectral analysis of arterial blood pressure and cerebral blood flow velocity during supine rest and orthostasis. / Chern, Chang Ming; Kuo, Terry Bo Jau; Sheng, Wen Yung; Wong, Wen Jang; Luk, Yung On; Hsu, Li Chi; Hu, Han Hwa.

In: Journal of Cerebral Blood Flow and Metabolism, Vol. 19, No. 10, 1999, p. 1136-1141.

Research output: Contribution to journalArticle

Chern, Chang Ming ; Kuo, Terry Bo Jau ; Sheng, Wen Yung ; Wong, Wen Jang ; Luk, Yung On ; Hsu, Li Chi ; Hu, Han Hwa. / Spectral analysis of arterial blood pressure and cerebral blood flow velocity during supine rest and orthostasis. In: Journal of Cerebral Blood Flow and Metabolism. 1999 ; Vol. 19, No. 10. pp. 1136-1141.
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