Specific integration of REV proviruses in avian bursal lymphomas

M. Reza Noori-Daloii, Robert A. Swift, Hsing Jien Kung, Lyman B. Crittenden, Richard L. Witter

Research output: Contribution to journalArticle

65 Citations (Scopus)

Abstract

The most common naturally occurring cancer of chickens associated with retrovirus infection is lymphoid leukosis (LL), a bursa (B) cell lymphoma. The primary causative agents are avian lymphoid ukosis viruses (LLVs), which do not necessarily have an oncogene. Recent evidence of Hayward et al.1 suggests that LLV infection promotes the expression of a cellular gene, c-myc (homologous to the oncogene of acute leukaemia virus, MC-29) thereby triggering the transformation process. In the majority of the tumours induced by LLV, the pro virus is integrated next to the c-myc gene (refs 1,3,18,19). To examine further the specific involvement of c-myc in lymphocytic transformation, we exploited our previous findings that replication-competent or non-defective reticuloendotheliosis virus (nd REV), genetically unrelated to LLV, are also capable of inducing lymphoma in chickens, with similar latent period and pathology to LL5. We have characterized the structure of the nd REV proviruses in the induced tumours and report here that proviral DNA is integrated next to c-myc in over 90% of the tumours analysed. This finding strengthens the hypothesis that the c-myc and its adjacent sequences are important in B-lymphocyte transformation. We also obtained evidence that amplification and structural alteration of the chromosomal region encompassing the REV provirus and c-myc gene have occurred during tumorigenesis in some of the tumours.

Original languageEnglish
Pages (from-to)574-576
Number of pages3
JournalNature
Volume294
Issue number5841
DOIs
Publication statusPublished - Dec 1 1981
Externally publishedYes

Fingerprint

Virus Integration
Lymphoma
myc Genes
Reticuloendotheliosis virus
Proviruses
Neoplasms
Viruses
Oncogenes
Chickens
Retroviridae Infections
B-Cell Lymphoma
Lymphocyte Activation
Carcinogenesis
Leukemia
B-Lymphocytes
Pathology
DNA
Infection

ASJC Scopus subject areas

  • Medicine(all)
  • General

Cite this

Noori-Daloii, M. R., Swift, R. A., Kung, H. J., Crittenden, L. B., & Witter, R. L. (1981). Specific integration of REV proviruses in avian bursal lymphomas. Nature, 294(5841), 574-576. https://doi.org/10.1038/294574a0

Specific integration of REV proviruses in avian bursal lymphomas. / Noori-Daloii, M. Reza; Swift, Robert A.; Kung, Hsing Jien; Crittenden, Lyman B.; Witter, Richard L.

In: Nature, Vol. 294, No. 5841, 01.12.1981, p. 574-576.

Research output: Contribution to journalArticle

Noori-Daloii, MR, Swift, RA, Kung, HJ, Crittenden, LB & Witter, RL 1981, 'Specific integration of REV proviruses in avian bursal lymphomas', Nature, vol. 294, no. 5841, pp. 574-576. https://doi.org/10.1038/294574a0
Noori-Daloii MR, Swift RA, Kung HJ, Crittenden LB, Witter RL. Specific integration of REV proviruses in avian bursal lymphomas. Nature. 1981 Dec 1;294(5841):574-576. https://doi.org/10.1038/294574a0
Noori-Daloii, M. Reza ; Swift, Robert A. ; Kung, Hsing Jien ; Crittenden, Lyman B. ; Witter, Richard L. / Specific integration of REV proviruses in avian bursal lymphomas. In: Nature. 1981 ; Vol. 294, No. 5841. pp. 574-576.
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