Specific chromosome defect associated with human small-cell lung cancer: Deletion 3p(14-23)

J. Whang-Peng, C. S. Kao-Shan, E. C. Lee, P. A. Bunn, D. N. Carney, A. F. Gazdar, J. D. Minna

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Abstract

A specific, acquired chromosomal abnormality (deletion 3p) has been found in at least one chromosome 3 in 100 percent of the metaphases in 12 of 12 cell lines cultured from human small-cell lung cancer tissue and in 2-day tumor culture specimens from three patients. Analysis of the shortest region of overlap shows the deletion to be 3p(14-23). This specific change was not seen in five of five lung cancer cell lines other than small-cell lung cancer or in two lymphoblastoid lines cultured from cells of small-cell lung cancer patients whose tumors had the 3p deletion.

Original languageEnglish
Pages (from-to)181-182
Number of pages2
JournalScience
Volume215
Issue number4529
Publication statusPublished - Jan 1 1982
Externally publishedYes

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ASJC Scopus subject areas

  • Medicine(all)
  • General

Cite this

Whang-Peng, J., Kao-Shan, C. S., Lee, E. C., Bunn, P. A., Carney, D. N., Gazdar, A. F., & Minna, J. D. (1982). Specific chromosome defect associated with human small-cell lung cancer: Deletion 3p(14-23). Science, 215(4529), 181-182.