Sparing Immunosuppression in Heart Transplant Recipients With Severe Sepsis

N. K. Chou, W. J. Ko, N. H. Chi, Y. S. Chen, H. Y. Yu, R. B. Hsu, C. T. Fang, S. C. Chang, F. Y. Lin, S. H. Chu, S. S. Wang

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

This study described an analysis of severe sepsis among heart transplantation recipients who were treated by sparing all immunosuppressants. Sepsis leading to multiple organ failure (MOF) in heart transplantation has a high mortality. This retrospective study of 190 patients who underwent heart transplantation from 1993 to 2004 included 12 who had severe sepsis with MOF who were treated by sparing all immunosuppressants. Half of them survived after sparing all immunosuppressants with intensive endomyocardial biopsy. Only one case needed pulse therapy for an acute rejection episode. The most common bacterial infectious episodes were caused by methicillin-resistant Staphylococcus aureus (n = 3). All sepsis episodes occurred in the first month after heart transplantation except in one case, which occurred 6 years after heart transplantation. There was a 50% survival rate of heart transplantation recipients who experienced MOF due to severe sepsis and were treated by sparing all immunosuppressants under a program of intensive endomyocardial biopsy.

Original languageEnglish
Pages (from-to)2145-2146
Number of pages2
JournalTransplantation Proceedings
Volume38
Issue number7
DOIs
Publication statusPublished - Sep 2006
Externally publishedYes

Fingerprint

Heart Transplantation
Immunosuppression
Sepsis
Immunosuppressive Agents
Multiple Organ Failure
Biopsy
Methicillin-Resistant Staphylococcus aureus
Pulse
Transplant Recipients
Survival Rate
Retrospective Studies
Mortality

ASJC Scopus subject areas

  • Surgery
  • Transplantation

Cite this

Chou, N. K., Ko, W. J., Chi, N. H., Chen, Y. S., Yu, H. Y., Hsu, R. B., ... Wang, S. S. (2006). Sparing Immunosuppression in Heart Transplant Recipients With Severe Sepsis. Transplantation Proceedings, 38(7), 2145-2146. https://doi.org/10.1016/j.transproceed.2006.06.009

Sparing Immunosuppression in Heart Transplant Recipients With Severe Sepsis. / Chou, N. K.; Ko, W. J.; Chi, N. H.; Chen, Y. S.; Yu, H. Y.; Hsu, R. B.; Fang, C. T.; Chang, S. C.; Lin, F. Y.; Chu, S. H.; Wang, S. S.

In: Transplantation Proceedings, Vol. 38, No. 7, 09.2006, p. 2145-2146.

Research output: Contribution to journalArticle

Chou, NK, Ko, WJ, Chi, NH, Chen, YS, Yu, HY, Hsu, RB, Fang, CT, Chang, SC, Lin, FY, Chu, SH & Wang, SS 2006, 'Sparing Immunosuppression in Heart Transplant Recipients With Severe Sepsis', Transplantation Proceedings, vol. 38, no. 7, pp. 2145-2146. https://doi.org/10.1016/j.transproceed.2006.06.009
Chou, N. K. ; Ko, W. J. ; Chi, N. H. ; Chen, Y. S. ; Yu, H. Y. ; Hsu, R. B. ; Fang, C. T. ; Chang, S. C. ; Lin, F. Y. ; Chu, S. H. ; Wang, S. S. / Sparing Immunosuppression in Heart Transplant Recipients With Severe Sepsis. In: Transplantation Proceedings. 2006 ; Vol. 38, No. 7. pp. 2145-2146.
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