Soy β-conglycinin retards progression of diabetic nephropathy via modulating the insulin sensitivity and angiotensin-converting enzyme activity in rats fed with high salt diet

Wan Ju Yeh, Hsin Yi Yang, Jiun-Rong Chen

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Abstract

Soy protein was known to have renal-protective effects. The aim of this study was to investigate the effects of different doses of soybean β-conglycinin, one of the main storage proteins in soy, on diabetic nephropathy in the rat. We used 40 Wistar rats with eight rats in each group. Diabetes mellitus was induced in rats by an intravenous injection of streptozotocin. The groups included a control group (Ctrl) fed with the standard AIN93-M diet, while other groups were fed with AIN-93M with the addition of NaCl to induce diabetic nephropathy (DN). DN rats were divided into the DN control (DN) group, the soy protein (DN + SP) group, the low-dose β-conglycinin (DN + B) group, and the high-dose β-conglycinin (DN + 2B) group. After a 27 weeks experimental period, we found that soy protein and β-conglycinin decreased blood glucose via increasing the insulin sensitivity, with an enhanced cholesterol-lowering effect of β-conglycinin-mediated hepatic LDL receptor protein expression. Otherwise, there were beneficial effects of soy protein and β-conglycinin on renal function markers. Through the inhibition of angiotensin-converting enzyme (ACE), soy protein and β-conglycinin retarded the progression of diabetic nephropathy by decreasing the blood pressure and histological changes. In conclusion, soy protein and β-conglycinin may retard the progression of diabetic nephropathy by increasing insulin sensitivity, regulating lipid metabolism, improving renal function markers, and inhibiting ACE activity.

Original languageEnglish
Pages (from-to)2898-2904
Number of pages7
JournalFood and Function
Volume5
Issue number11
DOIs
Publication statusPublished - Nov 1 2014

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diabetic nephropathy
peptidyl-dipeptidase A
Diabetic Nephropathies
Peptidyl-Dipeptidase A
insulin resistance
Insulin Resistance
Soybean Proteins
Salts
enzyme activity
Diet
salts
soy protein
rats
diet
renal function
Kidney
renoprotective effect
dosage
cholesteremic effect
LDL Receptors

ASJC Scopus subject areas

  • Food Science
  • Medicine(all)

Cite this

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title = "Soy β-conglycinin retards progression of diabetic nephropathy via modulating the insulin sensitivity and angiotensin-converting enzyme activity in rats fed with high salt diet",
abstract = "Soy protein was known to have renal-protective effects. The aim of this study was to investigate the effects of different doses of soybean β-conglycinin, one of the main storage proteins in soy, on diabetic nephropathy in the rat. We used 40 Wistar rats with eight rats in each group. Diabetes mellitus was induced in rats by an intravenous injection of streptozotocin. The groups included a control group (Ctrl) fed with the standard AIN93-M diet, while other groups were fed with AIN-93M with the addition of NaCl to induce diabetic nephropathy (DN). DN rats were divided into the DN control (DN) group, the soy protein (DN + SP) group, the low-dose β-conglycinin (DN + B) group, and the high-dose β-conglycinin (DN + 2B) group. After a 27 weeks experimental period, we found that soy protein and β-conglycinin decreased blood glucose via increasing the insulin sensitivity, with an enhanced cholesterol-lowering effect of β-conglycinin-mediated hepatic LDL receptor protein expression. Otherwise, there were beneficial effects of soy protein and β-conglycinin on renal function markers. Through the inhibition of angiotensin-converting enzyme (ACE), soy protein and β-conglycinin retarded the progression of diabetic nephropathy by decreasing the blood pressure and histological changes. In conclusion, soy protein and β-conglycinin may retard the progression of diabetic nephropathy by increasing insulin sensitivity, regulating lipid metabolism, improving renal function markers, and inhibiting ACE activity.",
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