Sources of superoxide radicals involved in the pathogenesis of diethyldithiocarbamate-induced gastric antral ulcer in rats

Sheng Hsuan Chen, Shiann Pan

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9 Citations (Scopus)

Abstract

The production of superoxide radicals as a result of decreased Cu,Zn-superoxide dismutase activity is considered to be the most important factor in the pathogenesis of diethyldithiocarbamate (DDC)-induced gastric antral ulcers in rats. The aim of the present study was to identify possible sources of superoxide radicals and the role of platelet-activating factor (PAF) in DDC-induced ulcer formation. Groups of rats were pretreated with a drug or antiserum before DDC (800 mg/ kg) administration. The size of the DDC-induced gastric antral ulcers was measured. Pretreatment with anti-rat polymorphonuclear leukocyte serum or CV-3988 (a specific antagonist of PAF) 20 mg/kg significantly reduced the size of DDC-induced gastric antral ulcers. The results confirmed that superoxide radicals play an important role in the pathogenesis of DDC-induced gastric ulcer in rats and suggested that NADH (reduced nicotinamide-adenine dinucleotide phosphate) oxidase in PAF-activated polymorphonuclear leukocytes may be involved in the generation of these radicals.

Original languageEnglish
Pages (from-to)131-134
Number of pages4
JournalJournal of the Formosan Medical Association
Volume97
Issue number2
Publication statusPublished - Feb 1998

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Keywords

  • Gastric ulcer
  • Neutrophil
  • Platelet-activating factor
  • Superoxide dismutase
  • Superoxide radical

ASJC Scopus subject areas

  • Medicine(all)

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