Sorting nexin 24 genetic variation associates with coronary artery aneurysm severity in Kawasaki disease patients

Ying Ju Lin, Jeng Sheng Chang, Xiang Liu, Ting Hsu Lin, Shao Mei Huang, Chiu Chu Liao, Cheng Wen Lin, Wen Kuei Chien, Jin Hua Chen, Jer Yuarn Wu, Chien Hsiun Chen, Li Ching Chang, Hsinyi Tsang, Kuan Teh Jeang, Chia Yen Chen, Fuu Jen Tsai

Research output: Contribution to journalArticle

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Abstract

Background: The sorting nexin (SNX) family is involved in endocytosis and protein trafficking and plays multiple roles in various diseases. The role of SNX proteins in Kawasaki disease (KD) is not known. We attempted to test whether genetic SNX variation associates with the risk of coronary artery aneurysm (CAA) formation in KD.Methods and results: Chi-square tests were used to identify SNX24 genetic variants associated with KD susceptibility and CAA formation in KD; models were adjusted for fever duration and time of first administration of intravenous immunoglobulin. We obtained clinical characteristics and genotypes from KD patients (76 with CAA and 186 without CAA) in a population-based retrospective KD cohort study (n = 262). Clinical and genetic factors were associated with CAA formation in KD. In addition, endothelial cell inflammation was evaluated. Significant correlation was observed between KD with CAA complications and the rs28891 single-nucleotide polymorphism in SNX24. Patients with CC + CT genotypes had lesser CAA complications. In lipopolysaccharide-treated human umbilical vein endothelial cells, siRNA knockdown of SNX24 significantly decreased gene expression of the proinflammatory cytokines IL-1 beta, IL-6, and IL-8.Conclusions: Polymorphisms in SNX24 may be used as genetic markers for the diagnosis and prognosis of CAA formation in KD.

Original languageEnglish
Article number44
JournalCell and Bioscience
Volume3
Issue number1
DOIs
Publication statusPublished - Nov 22 2013

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Sorting Nexins
Coronary Aneurysm
Mucocutaneous Lymph Node Syndrome
Coronary Vessels
Endothelial cells
Polymorphism
Genotype
Intravenous Immunoglobulins
Disease Susceptibility
Human Umbilical Vein Endothelial Cells
Protein Transport
Chi-Square Distribution
Endocytosis
Interleukin-8
Interleukin-1beta
Genetic Markers
Small Interfering RNA
Single Nucleotide Polymorphism
Lipopolysaccharides
Gene expression

Keywords

  • Coronary artery aneurysm
  • Kawasaki disease
  • Polymorphism
  • Sorting nexin 24

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

Cite this

Lin, Y. J., Chang, J. S., Liu, X., Lin, T. H., Huang, S. M., Liao, C. C., ... Tsai, F. J. (2013). Sorting nexin 24 genetic variation associates with coronary artery aneurysm severity in Kawasaki disease patients. Cell and Bioscience, 3(1), [44]. https://doi.org/10.1186/2045-3701-3-44

Sorting nexin 24 genetic variation associates with coronary artery aneurysm severity in Kawasaki disease patients. / Lin, Ying Ju; Chang, Jeng Sheng; Liu, Xiang; Lin, Ting Hsu; Huang, Shao Mei; Liao, Chiu Chu; Lin, Cheng Wen; Chien, Wen Kuei; Chen, Jin Hua; Wu, Jer Yuarn; Chen, Chien Hsiun; Chang, Li Ching; Tsang, Hsinyi; Jeang, Kuan Teh; Chen, Chia Yen; Tsai, Fuu Jen.

In: Cell and Bioscience, Vol. 3, No. 1, 44, 22.11.2013.

Research output: Contribution to journalArticle

Lin, YJ, Chang, JS, Liu, X, Lin, TH, Huang, SM, Liao, CC, Lin, CW, Chien, WK, Chen, JH, Wu, JY, Chen, CH, Chang, LC, Tsang, H, Jeang, KT, Chen, CY & Tsai, FJ 2013, 'Sorting nexin 24 genetic variation associates with coronary artery aneurysm severity in Kawasaki disease patients', Cell and Bioscience, vol. 3, no. 1, 44. https://doi.org/10.1186/2045-3701-3-44
Lin, Ying Ju ; Chang, Jeng Sheng ; Liu, Xiang ; Lin, Ting Hsu ; Huang, Shao Mei ; Liao, Chiu Chu ; Lin, Cheng Wen ; Chien, Wen Kuei ; Chen, Jin Hua ; Wu, Jer Yuarn ; Chen, Chien Hsiun ; Chang, Li Ching ; Tsang, Hsinyi ; Jeang, Kuan Teh ; Chen, Chia Yen ; Tsai, Fuu Jen. / Sorting nexin 24 genetic variation associates with coronary artery aneurysm severity in Kawasaki disease patients. In: Cell and Bioscience. 2013 ; Vol. 3, No. 1.
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abstract = "Background: The sorting nexin (SNX) family is involved in endocytosis and protein trafficking and plays multiple roles in various diseases. The role of SNX proteins in Kawasaki disease (KD) is not known. We attempted to test whether genetic SNX variation associates with the risk of coronary artery aneurysm (CAA) formation in KD.Methods and results: Chi-square tests were used to identify SNX24 genetic variants associated with KD susceptibility and CAA formation in KD; models were adjusted for fever duration and time of first administration of intravenous immunoglobulin. We obtained clinical characteristics and genotypes from KD patients (76 with CAA and 186 without CAA) in a population-based retrospective KD cohort study (n = 262). Clinical and genetic factors were associated with CAA formation in KD. In addition, endothelial cell inflammation was evaluated. Significant correlation was observed between KD with CAA complications and the rs28891 single-nucleotide polymorphism in SNX24. Patients with CC + CT genotypes had lesser CAA complications. In lipopolysaccharide-treated human umbilical vein endothelial cells, siRNA knockdown of SNX24 significantly decreased gene expression of the proinflammatory cytokines IL-1 beta, IL-6, and IL-8.Conclusions: Polymorphisms in SNX24 may be used as genetic markers for the diagnosis and prognosis of CAA formation in KD.",
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AU - Chang, Jeng Sheng

AU - Liu, Xiang

AU - Lin, Ting Hsu

AU - Huang, Shao Mei

AU - Liao, Chiu Chu

AU - Lin, Cheng Wen

AU - Chien, Wen Kuei

AU - Chen, Jin Hua

AU - Wu, Jer Yuarn

AU - Chen, Chien Hsiun

AU - Chang, Li Ching

AU - Tsang, Hsinyi

AU - Jeang, Kuan Teh

AU - Chen, Chia Yen

AU - Tsai, Fuu Jen

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