Sonogashira reaction of aryl and heteroaryl halides with terminal alkynes catalyzed by a highly efficient and recyclable nanosized MCM-41 anchored palladium bipyridyl complex

Bo Nan Lin, Shao Hsien Huang, Wei Yi Wu, Chung Yuan Mou, Fu Yu Tsai

Research output: Contribution to journalArticlepeer-review

68 Citations (Scopus)

Abstract

A heterogeneous catalyst, nanosized MCM-41-Pd, was used to catalyze the Sonogashira coupling of aryl and heteroaryl halides with terminal alkynes in the presence of CuI and triphenylphosphine. The coupling products were obtained in high yields using low Pd loadings to 0.01 mol%, and the nanosized MCM-41-Pd catalyst was recovered by centrifugation of the reaction solution and re-used in further runs without significant loss of reactivity.

Original languageEnglish
Pages (from-to)9157-9173
Number of pages17
JournalMolecules
Volume15
Issue number12
DOIs
Publication statusPublished - Dec 2010
Externally publishedYes

Keywords

  • Heterogeneous catalysis
  • Mesoporous silica
  • Palladium complex
  • Recyclable catalyst
  • Sonogashira reaction

ASJC Scopus subject areas

  • Analytical Chemistry
  • Chemistry (miscellaneous)
  • Molecular Medicine
  • Pharmaceutical Science
  • Drug Discovery
  • Physical and Theoretical Chemistry
  • Organic Chemistry

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