Somatostatin analogue mimics acute ischemic preconditioning in a rat model of myocardial infarction

Zong-Lun Wang, Yu H. Huang, Hang Chang

Research output: Contribution to journalArticle

10 Citations (Scopus)

Abstract

We tested the hypothesis that octreotide, a somatostatin analogue, can mimic ischemic preconditioning (PC) to provide cardioprotection against myocardial infarction. An ischemia-reperrusion model of adult Wistar rats was used. Infarct size was expressed as a percentage of the area at risk under different treatment protocols. Octreotide PC (35 μg/Kg 20 minutes before ischemia-reperfusion) significantly decreased infarct size (18 ± 4%) versus control (60 ± 7%). The somatostatin receptor antagonist cyclo-somatostatin (0.5 mg/Kg) could blunt the above cardioprotection. Administration of either chelerythrine (a protein kinase C inhibitor, 2 mg/Kg) or genistein (a tyrosine kinase inhibitor, 5 mg/Kg) could also block octreotide PC (54 ± 7% and 58 ± 6%, respectively). Pretreatment with the mitochondrial ATP-sensitive potassium channel antagonist 5-hydroxydecanoic acid (5-HD) and the sarcolemmal ATP-sensitive potassium channel antagonist glibenclamide could abolish the effects of octreotide PC (54 ± 6% and 52 ± 6%). Chelerythrine, however, had no effect on octreotide PC. In conclusion, the present study demonstrates that octreotide can mimic ischemic PC to reduce infarct size. Acute effects of octreotide PC involve the activation of protein kinase C, tyrosine kinase C, and mitochondrial ATP-sensitive potassium channels, but not systemic IGF-I activation.

Original languageEnglish
Pages (from-to)327-332
Number of pages6
JournalJournal of Cardiovascular Pharmacology
Volume45
Issue number4
DOIs
Publication statusPublished - Apr 2005

Keywords

  • Myocardial infarction
  • Receptors
  • Reperfusion
  • Signal transduction
  • Somatostatin

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Pharmacology

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