Solving the puzzle of pluripotent stem cell-derived cardiomyocyte maturation: Piece by piece

David J. Lundy, Desy S. Lee, Patrick C.H. Hsieh

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

There is a growing need for in vitro models which can serve as platforms for drug screening and basic research. Human adult cardiomyocytes cannot be readily obtained or cultured, and so pluripotent stem cell-derived cardiomyocytes appear to be an attractive option. Unfortunately, these cells are structurally and functionally immature-more comparable to foetal cardiomyocytes than adult. A recent study by Ruan et al., provides new insights into accelerating the maturation process and takes us a step closer to solving the puzzle of pluripotent stem cell-derived cardiomyocyte maturation.

Original languageEnglish
Article number143
JournalAnnals of Translational Medicine
Volume5
Issue number6
DOIs
Publication statusPublished - Mar 1 2017
Externally publishedYes

Fingerprint

Pluripotent Stem Cells
Cardiac Myocytes
Preclinical Drug Evaluations
Research

Keywords

  • Cardiomyocyte
  • Differentiation
  • Maturation
  • Stem cells

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Solving the puzzle of pluripotent stem cell-derived cardiomyocyte maturation : Piece by piece. / Lundy, David J.; Lee, Desy S.; Hsieh, Patrick C.H.

In: Annals of Translational Medicine, Vol. 5, No. 6, 143, 01.03.2017.

Research output: Contribution to journalArticle

@article{900e0346337e487db17bd12508b07ae2,
title = "Solving the puzzle of pluripotent stem cell-derived cardiomyocyte maturation: Piece by piece",
abstract = "There is a growing need for in vitro models which can serve as platforms for drug screening and basic research. Human adult cardiomyocytes cannot be readily obtained or cultured, and so pluripotent stem cell-derived cardiomyocytes appear to be an attractive option. Unfortunately, these cells are structurally and functionally immature-more comparable to foetal cardiomyocytes than adult. A recent study by Ruan et al., provides new insights into accelerating the maturation process and takes us a step closer to solving the puzzle of pluripotent stem cell-derived cardiomyocyte maturation.",
keywords = "Cardiomyocyte, Differentiation, Maturation, Stem cells",
author = "Lundy, {David J.} and Lee, {Desy S.} and Hsieh, {Patrick C.H.}",
year = "2017",
month = "3",
day = "1",
doi = "10.21037/atm.2017.01.44",
language = "English",
volume = "5",
journal = "Annals of Translational Medicine",
issn = "2305-5839",
publisher = "AME Publishing Company",
number = "6",

}

TY - JOUR

T1 - Solving the puzzle of pluripotent stem cell-derived cardiomyocyte maturation

T2 - Piece by piece

AU - Lundy, David J.

AU - Lee, Desy S.

AU - Hsieh, Patrick C.H.

PY - 2017/3/1

Y1 - 2017/3/1

N2 - There is a growing need for in vitro models which can serve as platforms for drug screening and basic research. Human adult cardiomyocytes cannot be readily obtained or cultured, and so pluripotent stem cell-derived cardiomyocytes appear to be an attractive option. Unfortunately, these cells are structurally and functionally immature-more comparable to foetal cardiomyocytes than adult. A recent study by Ruan et al., provides new insights into accelerating the maturation process and takes us a step closer to solving the puzzle of pluripotent stem cell-derived cardiomyocyte maturation.

AB - There is a growing need for in vitro models which can serve as platforms for drug screening and basic research. Human adult cardiomyocytes cannot be readily obtained or cultured, and so pluripotent stem cell-derived cardiomyocytes appear to be an attractive option. Unfortunately, these cells are structurally and functionally immature-more comparable to foetal cardiomyocytes than adult. A recent study by Ruan et al., provides new insights into accelerating the maturation process and takes us a step closer to solving the puzzle of pluripotent stem cell-derived cardiomyocyte maturation.

KW - Cardiomyocyte

KW - Differentiation

KW - Maturation

KW - Stem cells

UR - http://www.scopus.com/inward/record.url?scp=85016317195&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85016317195&partnerID=8YFLogxK

U2 - 10.21037/atm.2017.01.44

DO - 10.21037/atm.2017.01.44

M3 - Article

AN - SCOPUS:85016317195

VL - 5

JO - Annals of Translational Medicine

JF - Annals of Translational Medicine

SN - 2305-5839

IS - 6

M1 - 143

ER -