Solving the puzzle of pluripotent stem cell-derived cardiomyocyte maturation: Piece by piece

David J. Lundy, Desy S. Lee, Patrick C.H. Hsieh

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

There is a growing need for in vitro models which can serve as platforms for drug screening and basic research. Human adult cardiomyocytes cannot be readily obtained or cultured, and so pluripotent stem cell-derived cardiomyocytes appear to be an attractive option. Unfortunately, these cells are structurally and functionally immature-more comparable to foetal cardiomyocytes than adult. A recent study by Ruan et al., provides new insights into accelerating the maturation process and takes us a step closer to solving the puzzle of pluripotent stem cell-derived cardiomyocyte maturation.

Original languageEnglish
Article number143
JournalAnnals of Translational Medicine
Volume5
Issue number6
DOIs
Publication statusPublished - Mar 1 2017
Externally publishedYes

Keywords

  • Cardiomyocyte
  • Differentiation
  • Maturation
  • Stem cells

ASJC Scopus subject areas

  • Medicine(all)

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