Soluble receptor activator of nuclear factor-kB ligand (RANKL) and osteoprotegerin in ankylosing spondylitis: OPG is associated with poor physical mobility and reflects systemic inflammation

Chun Hsiung Chen, Hung An Chen, Hsien Tzung Liao, Chin Hsiu Liu, Chang Youh Tsai, Chung Tei Chou

Research output: Contribution to journalArticlepeer-review

32 Citations (Scopus)

Abstract

The objective of the study was to investigate the role of receptor activator of nuclear factor-kB ligand (RANKL) and osteoprotegerin (OPG) in ankylosing spondylitis (AS). Serum levels of soluble RANKL (sRANKL) and OPG were measured in 42 AS patients and 26 healthy controls. We evaluated the AS patient's disease activity, functional ability, global assessment, and physical mobility and tested markers of systemic inflammation, erythrocyte sedimentation rate (ESR), and Creactive protein (CRP) levels. Serum levels of sRANKL [mean (SD), 4.75 (1.88) vs. 3.70 (1.14) pmol/l, p=0.015] and OPG [mean (SD), 5.18 (1.19) vs. 4.52 (0.85) pmol/l, p=0.026] were significantly higher in the 42 AS patients than the 26 healthy controls. Interestingly, serum OPG levels correlated significantly with ESR (r=0.417, p= 0.007), CRP (r=0.524, p

Original languageEnglish
Pages (from-to)1155-1161
Number of pages7
JournalClinical Rheumatology
Volume29
Issue number10
DOIs
Publication statusPublished - 2010

Keywords

  • Ankylosing spondylitis
  • Inflammation
  • OPG
  • Physical mobility
  • RANKL

ASJC Scopus subject areas

  • Rheumatology

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