Snail as a potential marker for predicting the recurrence of prostate cancer in patients at stage T2 after radical prostatectomy

Yu-Ching Wen, Wei Yu Chen, Wei Jiunn Lee, Shun Fa Yang, Liang Ming Lee, Ming Hsien Chien

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

Background: We retrospectively investigated the relationship between immunohistochemical staining of radical prostatectomy (RP) specimens for snail and cancer recurrence. Methods: Seventy-six patients with prostate cancer who underwent RP were enrolled, and 53 patients were ultimately collected whose cancer was pathologically defined as T2. We detected the expression of snail using tissue microarrays. The snail image score was determined by the intensity. ×. tumor percentage, and a high score was defined as 8 (1-12 points). Results: The snail image scores and Gleason score sums were correlated with recurrence-free survival according to a log-rank test (p

Original languageEnglish
Pages (from-to)169-173
Number of pages5
JournalClinica Chimica Acta
Volume431
DOIs
Publication statusPublished - Apr 20 2014

Fingerprint

Snails
Microarrays
Prostatectomy
Tumors
Prostatic Neoplasms
Tissue
Recurrence
Neoplasms
Neoplasm Grading
Staining and Labeling
Survival

Keywords

  • Prostate cancer
  • Radical prostatectomy
  • Recurrence
  • Snail
  • Stage T2

ASJC Scopus subject areas

  • Biochemistry
  • Clinical Biochemistry
  • Biochemistry, medical
  • Medicine(all)

Cite this

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abstract = "Background: We retrospectively investigated the relationship between immunohistochemical staining of radical prostatectomy (RP) specimens for snail and cancer recurrence. Methods: Seventy-six patients with prostate cancer who underwent RP were enrolled, and 53 patients were ultimately collected whose cancer was pathologically defined as T2. We detected the expression of snail using tissue microarrays. The snail image score was determined by the intensity. ×. tumor percentage, and a high score was defined as 8 (1-12 points). Results: The snail image scores and Gleason score sums were correlated with recurrence-free survival according to a log-rank test (p",
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T1 - Snail as a potential marker for predicting the recurrence of prostate cancer in patients at stage T2 after radical prostatectomy

AU - Wen, Yu-Ching

AU - Chen, Wei Yu

AU - Lee, Wei Jiunn

AU - Yang, Shun Fa

AU - Lee, Liang Ming

AU - Chien, Ming Hsien

PY - 2014/4/20

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N2 - Background: We retrospectively investigated the relationship between immunohistochemical staining of radical prostatectomy (RP) specimens for snail and cancer recurrence. Methods: Seventy-six patients with prostate cancer who underwent RP were enrolled, and 53 patients were ultimately collected whose cancer was pathologically defined as T2. We detected the expression of snail using tissue microarrays. The snail image score was determined by the intensity. ×. tumor percentage, and a high score was defined as 8 (1-12 points). Results: The snail image scores and Gleason score sums were correlated with recurrence-free survival according to a log-rank test (p

AB - Background: We retrospectively investigated the relationship between immunohistochemical staining of radical prostatectomy (RP) specimens for snail and cancer recurrence. Methods: Seventy-six patients with prostate cancer who underwent RP were enrolled, and 53 patients were ultimately collected whose cancer was pathologically defined as T2. We detected the expression of snail using tissue microarrays. The snail image score was determined by the intensity. ×. tumor percentage, and a high score was defined as 8 (1-12 points). Results: The snail image scores and Gleason score sums were correlated with recurrence-free survival according to a log-rank test (p

KW - Prostate cancer

KW - Radical prostatectomy

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KW - Stage T2

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