Small F chromosome in myelo- and lymphoproliferative diseases

J. Whang-Peng, H. R. Gralnick, T. Knutsen, H. Brereton, P. Chang, G. P. Schechter, L. Lessin

Research output: Contribution to journalArticle

13 Citations (Scopus)

Abstract

A deleted F group chromosome was observed in five patients with myeloproliferative and lymphoproliferative diseases. Three patients had a small F chromosome with both arms deleted, 19p-q-. Each of these patients had a different disease, acute myelomonocytic leukemia (AMML), lymphosarcoma (LSA), and erythroleukemia, respectively. One patient had a hyperplastic marrow and erythroid hyperplasia for a year prior to the development of acute myelogenous leukemia (AML), and had a small F chromosome with del(20)(q12) which is similar to the small F chromosome reported in patients with polycythemia vera. No banding studies were available on one patient with sideroblastic anemia and possible erythroleukemia. These cytogenetic findings lead us to believe that: (1) there is a high incidence of F chromosome abnormalities in cases with abnormal erythropoiesis; (2) erythroid diseases may be predisposed to the small F chromosome abnormality, which is enhanced by treatment, such as irradiation; and (3) the cells with a small F chromosome are rather stable and can gradually replace cytogenetically normal cells without affecting the clinical course of the diseases, and it is the emergence of additional chromosomal abnormalities in these cells which signal a poor prognosis.

Original languageEnglish
Pages (from-to)19-30
Number of pages12
JournalLeukemia Research
Volume1
Issue number1
DOIs
Publication statusPublished - Jan 1 1977
Externally publishedYes

Fingerprint

Chromosomes, Human, 19-20
Chromosome Aberrations
Leukemia, Erythroblastic, Acute
Sideroblastic Anemia
Leukemia, Myelomonocytic, Acute
Polycythemia Vera
Erythropoiesis
Acute Myeloid Leukemia
Cytogenetics
Non-Hodgkin's Lymphoma
Hyperplasia
Bone Marrow
Incidence

ASJC Scopus subject areas

  • Hematology
  • Oncology
  • Cancer Research

Cite this

Whang-Peng, J., Gralnick, H. R., Knutsen, T., Brereton, H., Chang, P., Schechter, G. P., & Lessin, L. (1977). Small F chromosome in myelo- and lymphoproliferative diseases. Leukemia Research, 1(1), 19-30. https://doi.org/10.1016/0145-2126(77)90061-3

Small F chromosome in myelo- and lymphoproliferative diseases. / Whang-Peng, J.; Gralnick, H. R.; Knutsen, T.; Brereton, H.; Chang, P.; Schechter, G. P.; Lessin, L.

In: Leukemia Research, Vol. 1, No. 1, 01.01.1977, p. 19-30.

Research output: Contribution to journalArticle

Whang-Peng, J, Gralnick, HR, Knutsen, T, Brereton, H, Chang, P, Schechter, GP & Lessin, L 1977, 'Small F chromosome in myelo- and lymphoproliferative diseases', Leukemia Research, vol. 1, no. 1, pp. 19-30. https://doi.org/10.1016/0145-2126(77)90061-3
Whang-Peng J, Gralnick HR, Knutsen T, Brereton H, Chang P, Schechter GP et al. Small F chromosome in myelo- and lymphoproliferative diseases. Leukemia Research. 1977 Jan 1;1(1):19-30. https://doi.org/10.1016/0145-2126(77)90061-3
Whang-Peng, J. ; Gralnick, H. R. ; Knutsen, T. ; Brereton, H. ; Chang, P. ; Schechter, G. P. ; Lessin, L. / Small F chromosome in myelo- and lymphoproliferative diseases. In: Leukemia Research. 1977 ; Vol. 1, No. 1. pp. 19-30.
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