Sleep disruption in spinocerebellar ataxia type 3: A genetic and polysomnographic study

Nai Fang Chi, Guang Ming Shiao, Hsiao Lun Ku, Bing Wen Soong

Research output: Contribution to journalArticle

10 Citations (Scopus)

Abstract

Background: Sleep structure disruption and rapid eye movement (REM) sleep behavior disorders (RBD) have been previously reported in patients with neurodegenerative diseases. However, similar studies have rarely been quantitatively conducted in type 3 spinocerebellar ataxia (SCA3). Methods: Fifteen patients with SCA3 and 16 healthy controls were recruited and evaluated by clinical history, International Cooperative Ataxia Rating Scale (ICARS), Epworth sleepiness scale (ESS), and polysomnography. Results: Patients with SCA3 had reductions in sleep efficiency and percentage of REM sleep, which were negatively correlated with the severity of ataxia as evaluated by ICARS. REM sleep reduction occurred regardless of the presence of RBD, and severe reduction of REM sleep may significantly disturb the assessment of RBD. Conclusion: Poor sleep efficiency and REM sleep aberrations are the characteristics of sleep structure disruption in SCA3 as the disease progresses. The incidence of respiratory disturbance during sleep or excessive daytime sleepiness was not significantly higher in SCA3 patients than controls.

Original languageEnglish
Pages (from-to)25-30
Number of pages6
JournalJournal of the Chinese Medical Association
Volume76
Issue number1
DOIs
Publication statusPublished - Jan 2013

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Machado-Joseph Disease
Sleep
REM Sleep Behavior Disorder
REM Sleep
Ataxia
Polysomnography
Neurodegenerative Diseases

Keywords

  • Polysomnography
  • REM sleep behavior disorder
  • Spinocerebellar ataxia

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Sleep disruption in spinocerebellar ataxia type 3 : A genetic and polysomnographic study. / Chi, Nai Fang; Shiao, Guang Ming; Ku, Hsiao Lun; Soong, Bing Wen.

In: Journal of the Chinese Medical Association, Vol. 76, No. 1, 01.2013, p. 25-30.

Research output: Contribution to journalArticle

Chi, Nai Fang ; Shiao, Guang Ming ; Ku, Hsiao Lun ; Soong, Bing Wen. / Sleep disruption in spinocerebellar ataxia type 3 : A genetic and polysomnographic study. In: Journal of the Chinese Medical Association. 2013 ; Vol. 76, No. 1. pp. 25-30.
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