Size effect on cell uptake in well-suspended, uniform mesoporous silica nanoparticles

Fang Lu, Si Han Wu, Yann Hung, Chung Yuan Mou

Research output: Contribution to journalArticle

659 Citations (Scopus)

Abstract

A study was conducted to demonstrate the synthesis of monodisperse mesoporous silica nanoparticle (MSN) suspensions and investigate the effect of nanoparticle size on cell uptake. The MSNs were synthesized by adjusting the pH of the reaction medium, leading to a series of MSNs with uniform size ranging from 30-280 nm. The physical properties of the MSNs were characterized with various methods, such as nitrogen adsorption-desorption, transmission electron microscopy (TEM), and X-ray powder diffraction (XRD). The particle size effect on the cell uptake efficiency with human cervical cancer cells and cellular uptake of MSNs of various sizes were investigated by confocal laser scanning microscopy (CLSM). The uptake efficiencies were determined by inductively coupled plasma mass spectrometry (ICP-MS) analysis of total silicon content.

Original languageEnglish
Pages (from-to)1408-1413
Number of pages6
JournalSmall
Volume5
Issue number12
DOIs
Publication statusPublished - Jun 19 2009
Externally publishedYes

Keywords

  • Cell uptake
  • Mesoporous materials
  • Nanoparticles
  • Particle size
  • Silica

ASJC Scopus subject areas

  • Biomaterials
  • Engineering (miscellaneous)
  • Biotechnology

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